Status:
ACTIVE_NOT_RECRUITING
A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Conditions:
High-grade Glioma
Brain Metastases
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
The purpose of this study is to find out whether 68Ga-PSMA-11 PET/CT is effective in assessing tumor uptake (tumor activity seen in cancerous tissue) in participants with high-grade glioma/HGG or brai...
Eligibility Criteria
Inclusion
- Ability to understand and the willingness to sign (or their legally acceptable representative (LAR) must sign) a written informed consent document
- Adults ≥ 18 years old
- Suspicion for or histologically or cytologically confirmed and previously treated HGG or brain metastases from a primary extracranial malignancy
- Lesion size ≥ 1 cm (for the lesion to be biopsied)
- ECOG performance status ≤ 2 (Karnofsky ≥ 60%)
- Planned to undergo biopsy/resection of brain lesion
Exclusion
- Inability to undergo a PET scan (e.g., claustrophobia or noncompatible implant in case PET/MR is performed)
- Pregnant or nursing female. All women of childbearing potential must have a documented negative serum or urine pregnancy test \<1 week before study.
- Uncontrolled, intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiacarrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
- Patients with severe allergy to both iodinated and gadolinium contrast.
Key Trial Info
Start Date :
January 5 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 5 2027
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT06209567
Start Date
January 5 2024
End Date
January 5 2027
Last Update
December 3 2025
Active Locations (7)
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1
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
2
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey, United States, 07748
3
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey, United States, 07645
4
Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities)
Commack, New York, United States, 11725