Status:
TERMINATED
C752 for Refractory/Relapsed B Cell Non-Hodgkin Lymphoma
Lead Sponsor:
920th Hospital of Joint Logistics Support Force of People's Liberation Army of China
Collaborating Sponsors:
Shanghai PerHum Therapeutics Co., Ltd.
Conditions:
Lymphoma, B-Cell
CAR-T
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
It is a single-arm, open-label clinical study to assess the safety and efficacy of the C752 CAR-T Cells for patients with CD19+ refractory/relapsed B cell non-Hodgkin lymphoma.
Eligibility Criteria
Inclusion
- Written informed consent in accordance with federal, local, and institutional guidelines, Males and females ≥18 years of age at the time of consent
- Documented diagnosis of Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
- Have progression by least one systemic treatment and no available standard of care treatment.
- At least one measurable lesion by Lugano 2014
- Expected survival ≥ 12 weeks
- Have an ECOG performance status of 0 or 1
- Adequate organ function
- Screening test indicates histopathological CD19 + if the subject received CD19-targeted therapy
- Women of childbearing age must have a negative pregnancy test, and agree to take effective contraception during the trial
Exclusion
- Treatment with any prior HSCT, gene therapy product, cell therapy product ect.
- Central nervous system involvement
- HBV/HCV
- HIV infection
- Concurrent use of systemic steroids or immunosuppression
- Uncontrolled active infection
- Wash-out period of from the last anti-cancer treatment
- Active second malignancy
- Have not recovered from the effects of previous therapy
- Have psychological or physical conditions that do not permit compliance with the protocol
- Pregnant or nursing (lactating) women
Key Trial Info
Start Date :
December 24 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 24 2024
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT06210243
Start Date
December 24 2023
End Date
December 24 2024
Last Update
February 18 2025
Active Locations (1)
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1
920th Hospital of Joint LogisticsSupport Force of People's Liberation
Kunming, Yunnan, China, 650000