Status:
COMPLETED
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study
Lead Sponsor:
University Hospital Southampton NHS Foundation Trust
Collaborating Sponsors:
University of Southampton
Conditions:
Urolithiasis
Eligibility:
All Genders
18+ years
Brief Summary
Many things, like not drinking enough fluids, contribute to making kidney stones and there is also a genetic tendency. We looked into this in 1998-2000 in 14 families with several stone-formers. In fo...
Detailed Description
Background: There is an underlying genetic component to formation of calcium kidney stones, with heritability estimated at about 50%. In most stone formers, genetic susceptibility is polygenic with c...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Stone-forming families who participated in our 1998-2000 study
- Apparent autosomal dominant inheritance of stones transmitted through one line of the family.
- Calcium kidney stone formers.
- Men and women aged 18 year or over.
- Exclusion criteria.
- A known hereditary cause of stones
- Children under 18 years of age.
- Uric acid stone formers.
Exclusion
Key Trial Info
Start Date :
October 12 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 8 2023
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT06211842
Start Date
October 12 2016
End Date
November 8 2023
Last Update
January 19 2024
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