Status:
COMPLETED
Bace1as Role in Heart Failure (BACE1AS-HF)
Lead Sponsor:
IRCCS Policlinico S. Donato
Collaborating Sponsors:
Istituti Clinici Scientifici Maugeri di Pavia
Conditions:
Heart Failure
Acute Coronary Syndrome
Eligibility:
All Genders
18-75 years
Brief Summary
The objective of this project is 1) to explore the clinical relevance of BACE1-AS and BACE1 as therapeutic targets and 2) to evaluate their potentiality as biomarkers in ischemic heart failure (HF). ...
Detailed Description
1.1) Validation of transcriptomic data obtained in vitro: The transcriptome of the AC16 cardiomyocyte cell line in which the expression of BACE1-AS was induced by lentivirus vectors will be analyzed, ...
Eligibility Criteria
Inclusion
- Left ventricular biopsies from patients with post-ischemic HF
- left ventricular reconstruction surgery (SVR)
- ESVI \>35 ml/m2
- EF\<40%
- previous anterior transmural infarction
- age 40-75 years
Exclusion
- ESVI \<35 ml/m2
- EF\>40%
- Tempo from E unknown
- Pregnant women
- Patients with genetic diseases
- Patients suffering from malignant neoplasm
- Subjects with collagenopathies
- Subjects undergoing chemo/radiotherapy
- Subjects undergoing prolonged steroid therapy
- Subjects with known active infectious diseases
- Subjects with positive serology for HIV, HBV (not vaccinated), HCV.
- Patients with ACS and left ventricular dysfunction 12 months after percutaneous angioplasty
- Inclusion criteria:
- Age \>18 years
- Patients with ACS (first episode), defined according to the ESC 2017 guidelines \[19\]
- Informed consent to enrollment in the study
Key Trial Info
Start Date :
March 12 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 30 2024
Estimated Enrollment :
630 Patients enrolled
Trial Details
Trial ID
NCT06213493
Start Date
March 12 2021
End Date
November 30 2024
Last Update
April 30 2025
Active Locations (1)
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1
Irccs Policlinico San Donato
San Donato Milanese, Milan, Italy, 20097