Status:
COMPLETED
Immune Heterogeneity Before and After Cardiopulmonary Bypass in Children
Lead Sponsor:
The Children's Hospital of Zhejiang University School of Medicine
Conditions:
Ventricular Septal Defect
Eligibility:
All Genders
31-1 years
Brief Summary
The goal of this observational study is to learn about functional heterogeneity of immune cells before and after cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD). The main ...
Detailed Description
CPB-induced immune paralysis is the main cause of postoperative infection in CHD, which seriously affects the prognosis of children. The underlying mechanism of CPB-induced immune paralysis has not be...
Eligibility Criteria
Inclusion
- Birth weight range: 2500-6000g;
- Operation duration \>90min;
Exclusion
- preterm infants or preoperative infections;
- systemic immune diseases and serious complications: such as rheumatoid arthritis, systemic lupus erythematosus, severe liver and kidney function damage, leukemia, etc.;
- Patients who have received an organ transplant;
- Patients who have received immunomodulatory drugs: patients who have received immunomodulatory drugs before surgery;
- Parents refused to participate or were unable to provide sufficient samples: Parents or legal guardians refused to participate in the study.
Key Trial Info
Start Date :
January 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 31 2025
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT06214182
Start Date
January 1 2024
End Date
January 31 2025
Last Update
March 11 2025
Active Locations (1)
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1
Children's Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China