Status:
NOT_YET_RECRUITING
Urinary Parameters to Predict Weaning of Renal Replacement Therapy in the Critically Ill
Lead Sponsor:
University Hospital, Montpellier
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Data on the optimal period for RRT weaning in critically ill patient are scarce. The current practice for RRT weaning is based on urine output, the threshold of which is debatable. Two recent observat...
Detailed Description
RRT is an invasive high-cost treatment with potentially severe complications. However, there is a major dearth of data on RRT weaning in the ICU. The weaning strategy using only urine output is based ...
Eligibility Criteria
Inclusion
- Adults (18 years of age or older)
- Admitted to the ICU
- Receiving or having received invasive mechanical ventilation and/or catecholamine infusion (epinephrine or norepinephrine or dobutamine) at least 48h
- With acute kidney injury, at KDIGO 3 (See Appendix 1) stage and associated with oliguria at least \< 200ml/ 24h before RRT initiation
- Treated with intermittent or continuous renal replacement therapy
- Resumption of urine output \> 300ml/24h with or without diuretic use
Exclusion
- Preexisting Chronic kidney disease with estimated glomerular filtration rate (eGFR) \< 30ml/min
- AKI caused by vascular occlusion, glomerulonephritis, vasculitis, post-renal obstruction, thrombotic microangiopathy, tumor lysis syndrome
- RRT for another cause than AKI (eg: drug intoxication,...)
- Decision to forgo life-sustaining treatment including RRT
- Cirrhosis with Child-Pugh score of C or hepatorenal syndrome
- Kidney transplantation
- Patient already enrolled in the study
- Participation in another clinical trial assessing the impact or duration of RRT
- Pregnancy in progress or planned during the study period or breastfeeding women
- Patients protected by law (Art. L1121-6 and L1121-8 of the Code de la Santé Publique) : Adult protected by law or patient under guardianship or curatorship
- Subjects not covered by public health insurance
- Absence of written informed consent from the patient or his or her proxy (if present) before inclusion or when possible when the patient has been included in an emergency setting
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT06214390
Start Date
January 1 2024
End Date
December 1 2025
Last Update
January 19 2024
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Clermont-Ferrand Hospital University
Clermont-Ferrand, France
2
Montpellier University Hospital
Montpellier, France, 34295