Status:
RECRUITING
Study on Treatment Decision-Making and Prognostic Follow-Up for Untreated Cerebral Cavernous Malformations
Lead Sponsor:
Beijing Tiantan Hospital
Collaborating Sponsors:
RenJi Hospital
Beijing Chao Yang Hospital
Conditions:
Hemangioma, Cavernous, Central Nervous System
Eligibility:
All Genders
Brief Summary
The goal of this observational study is to evaluate and predict the risk associated with cerebral cavernous malformations (CCMs) using advanced artificial intelligence and radiomics analysis technolog...
Eligibility Criteria
Inclusion
- Diagnosis of CCM based on brain MRI (T1, T2, SWI, and T2-Fluid-Attenuated Inversion Recovery).
- Patients who have not received invasive treatment (surgery, radiotherapy, or multimodal therapy) in the past.
- Patients undergoing surgery, or their legal guardians, agree to collect lesion tissue samples for related studies and sign a consent form for the collection of biological samples.
- Patients under conservative observation, or their legal guardians, agree to collect imaging data for related research and sign a consent form for the use of imaging data.
- Willingness to participate in long-term follow-up.
Exclusion
- Patients with acute intracranial symptomatic hemorrhage requiring emergency surgery.
- Patients with other intracranial diseases, such as aneurysms, tumors, or other vascular malformations, excluding developmental venous anomalies (DVA).
- Patients with severe underlying diseases affecting their functional status and short-term life expectancy.
- Patients with severe psychiatric or psychological disorders.
- Incomplete clinical or imaging data.
Key Trial Info
Start Date :
September 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
1200 Patients enrolled
Trial Details
Trial ID
NCT06214767
Start Date
September 1 2020
End Date
June 30 2026
Last Update
July 30 2025
Active Locations (1)
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1
Capital Medical University Affiliated Beijing Tiantan Hospital
Beijing, Beijing Municipality, China