Status:
ACTIVE_NOT_RECRUITING
Choline to Prevent SAM in Children With MAM
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
Project Peanut Butter
Kamuzu University of Health Sciences
Conditions:
Moderate Acute Malnutrition
Eligibility:
All Genders
6-59 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to test choline supplementation in children with moderate acute malnutrition in Malawi. The main question it aims to answer is: Will provision of RUSF with added ch...
Detailed Description
Moderate acute malnutrition (MAM) is common among children worldwide, with a prevalence of 50M and an annual incidence likely 3-5x this number. It is defined by mid-upper arm circumference (MUAC) ≥ 11...
Eligibility Criteria
Inclusion
- 6-59 months of age
- uncomplicated MAM (mid-upper arm circumference (MUAC) ≥ 11.5 cm and \< 12.5 cm and/or weight-for-length z-score (WLZ) ≥ -3 and \< -2)
- availability for the duration of the study with no plan to move from the catchment area of a participating clinic
Exclusion
- presence of nutritional edema
- features of complicated MAM, such as mental status changes or breathing issues
- participation in another feeding program
- known allergy to study food ingredient
- intention to move away from catchment area within 9 months
- developmental delay
- presence of a chronic severe medical condition (other than TB or HIV) such as congenital heart disease
Key Trial Info
Start Date :
March 18 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
1500 Patients enrolled
Trial Details
Trial ID
NCT06214897
Start Date
March 18 2024
End Date
June 1 2026
Last Update
December 17 2025
Active Locations (10)
Enter a location and click search to find clinical trials sorted by distance.
1
Chikonde Health Center
Chikonde, Malawi
2
Chipolonga Health Center
Chipolonga, Malawi
3
Makhwira Health Center
Makhwira, Malawi
4
Mbiza Health Clinic
Mbiza, Malawi