Status:
COMPLETED
Optimizing Music-Based Interventions for Stroke
Lead Sponsor:
NYU Langone Health
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Stroke
Eligibility:
All Genders
18-89 years
Phase:
NA
Brief Summary
This study will enroll stroke patients and healthy participants. Participants will complete baseline measures followed by a music playing task during fMRI and simultaneous measurement of motor respons...
Eligibility Criteria
Inclusion
- For participants with stroke, to be eligible to participate in this study, an individual must meet all the following criteria:
- hemiparesis resulting from a stroke (ischemic or hemorrhagic) at least 6 months before the enrollment into the study
- age from 18 to 89 years
- ability to move the wrist flexor and extensor muscles without help from the healthy side, scoring above 3 on the Medical Research Council (MRC) Scale for Muscle Strength, reflecting active movement against gravity
- no more than mild resistance to passive movement in the wrist extensor muscle - as demonstrated by a score \<2 on the Ashworth Scale (Brashear et al.., 2002)
- a modified Rankin Scale (mRS) \< 3 indicating moderate to mild disability and the ability to ambulate independently (Bonita \& Beaglehole, 1988)
- ability to comprehend language and provide informed consent
- consenting to participate and willingness to complete MRI testing procedures
- For neurologically normal control (NC) participants, to be eligible to participate in this study, an individual must meet all the following criteria:
- be matched for age, gender, and socioeconomic status (education level) to a previously enrolled participant with stroke
- age from 18 to 89 years
- no history of neurological injury
- ability to comprehend language and provide informed consent
- consenting to participate and willingness to complete MRI testing procedures
Exclusion
- history of neurological injury other than stroke
- moderate to severe depression symptoms indicated by a score \>10 on the Patient Health Questionnaire - 9 (PHQ-9; Koenke et al., 2001; Williams et al., 2005)
- visual impairment unable to be corrected with glasses/contact lenses sufficient to allow reading comprehension
- actively performing or practicing a musical instrument more than 2 hours/week
- musical anhedonia indicated by a score \< 65 on the Barcelona Music Reward Questionnaire (BMRQ; Mas-Herrero et al., 2013)
- amusia as measured by the Montreal Battery of the Evaluation of Amusia (MBEA; Peretz et al., 2003)
- not being compatible with MRI testing, including having implanted devices, previous exposure to metallic fragments, large tattoos, claustrophobia, and pregnancy
Key Trial Info
Start Date :
February 16 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 8 2025
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT06215703
Start Date
February 16 2024
End Date
February 8 2025
Last Update
April 25 2025
Active Locations (1)
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1
NYU Langone Health
New York, New York, United States, 10016