Status:
RECRUITING
Evaluation of Amino Acid Metabolism Changes in Ovarian Cancer
Lead Sponsor:
University Hospital, Grenoble
Conditions:
Ovarian Cancer
Eligibility:
FEMALE
40-70 years
Phase:
NA
Brief Summary
Ovarian cancer is associated with undernutrition in more than half of all cases. The current management of undernutrition-cachexia in cancer is not specific. It is well recognized that the nutritional...
Eligibility Criteria
Inclusion
- Histological diagnosis of high-grade serous ovarian cancer not immediately resectable (stage III or IVa) managed at Grenoble Alpes University Hospital.
- Affiliation to the French social security system.
- Able to understand and follow the instructions necessary for the conduct of the trial, and having given written consent for the study.
Exclusion
- Significant active comorbidity requiring long-term drug treatment (e.g. organ failure, diabetes) or history of pathology likely to impact amino acid metabolism (e.g. urea or homocysteine cycle abnormalities, tyrosinemia, alkaptonuria, hyperprolinemia, organic aciduria).
- vegetarian or vegan diet
- difficult venous access
- Persons covered by articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons subject to a legal protection measure).
- Subject receiving more than 4,500 euros in compensation for participation in other research involving the human body in the 12 months preceding this study.
- Significant biological abnormalities (not explained by the underlying pathology for women with ovarian cancer)
- Liver metastases
Key Trial Info
Start Date :
March 11 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT06216496
Start Date
March 11 2024
End Date
December 1 2026
Last Update
May 20 2024
Active Locations (1)
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1
CHU Grenoble Alpes
La Tronche, France