Status:
RECRUITING
Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Cystic Fibrosis Foundation
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
13-20 years
Brief Summary
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in adolescents diagnosed with cystic fibrosis (CF) compared to healthy, matched controls. The investigators ...
Detailed Description
Less than optimal bone health has been seen in children that have cystic fibrosis (CF). This can present as low bone density or altered bone structure, weakening the bones and increasing fragility and...
Eligibility Criteria
Inclusion
- 13-20 years old
- Cystic fibrosis with pancreatic insufficiency
- Must have a stable treatment regimen, including CFTR modulator usage unchanged for the prior three months
- Liver transplant recipients will be eligible, as long as they are at least 1 year post-transplant and are no longer on Prednisone for immunosuppressive therapy
Exclusion
- Diagnosis of other chronic disease affecting bone health
- Active use (within the past 3 months) of medications that are known to affect skeletal metabolism
- CF exacerbation or glucocorticoid exposure within the prior 1 month
- Lung transplant
Key Trial Info
Start Date :
April 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2029
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT06216704
Start Date
April 1 2024
End Date
June 30 2029
Last Update
October 30 2025
Active Locations (1)
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1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115