Status:
NOT_YET_RECRUITING
Personalised Hyperlipidaemia Therapies Guided by Pharmacogenomics
Lead Sponsor:
National University of Singapore
Collaborating Sponsors:
Collabring Pte Ltd
Conditions:
Cardiovascular Diseases
Eligibility:
All Genders
21-75 years
Phase:
NA
Brief Summary
This trial aims to evaluate the impact of clinical pharmacists' pharmacogenomics-guided choice and statin titration for managing hyperlipidaemia. The central hypotheses of this trial are (1) clinical...
Detailed Description
The primary aims are: * The changes in Low-Density Lipoprotein cholesterol (LDL-c), total cholesterol, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-c) levels, and * The incidence...
Eligibility Criteria
Inclusion
- Participants between 21 and 75 years old
- Participants who are planning to start on statin\* medication or whose LDL-c goals have not been met, per Appendix B.
- Participants who are able to communicate in English, Chinese or Malay.
- Participants who are planning to start or will be started on the following doses are eligible: atorvastatin 10-80 mg/day, rosuvastatin 10-40 mg/day, or simvastatin 10-40 mg/day within the last two to four weeks before enrolment
Exclusion
- Participants who are statin-intolerant or in whom statins are contraindicated
- Participants on a statin dosing schedule of every other day (EOD)
- Participants administered on potent Cytochrome P450 3A4 (CYP3A4) or Cytochrome P450 2C9 (CYP2C9) or OATP inhibitors or inducers.
- Participants on evolocumab and alirocumab prior to enrolment
- Participants with documented diagnosis of psychiatric conditions
- Participants requiring palliative care, end-of-life care, or those with a life expectancy of less than one year
- Pregnant and lactating women
- Participants with complaints of myalgia or muscle weakness at baseline, before the commencement of statin
- Participants who are unable to swallow a whole statin tablet
Key Trial Info
Start Date :
April 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
700 Patients enrolled
Trial Details
Trial ID
NCT06217523
Start Date
April 1 2024
End Date
December 1 2025
Last Update
March 27 2024
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