Status:
RECRUITING
LCAT (Lecithin Cholesterol Acyl Transferase) Natural History Study
Lead Sponsor:
University of Pennsylvania
Conditions:
LCAT Deficiency
Eligibility:
All Genders
Brief Summary
The purpose of the LCAT (Lecithin cholesterol acyl transferase) Natural History Study (LCAT NHS) is to help identify people with a mutation in a gene called LCAT, collect and store information about t...
Eligibility Criteria
Inclusion
- Males or Females of any age
- Subjects with:
- a diagnosis of primary LCAT deficiency based on investigator assessment or laboratory results AND/OR
- a genetically confirmed mutation in the LCAT gene who are homozygous or compound heterozygous for LCAT loss-of-function mutations
- Subjects or their legal guardian must be able to comprehend and be willing to provide a signed institutional review board/ethics committee (IRB/EC) approved Informed Consent Form. A waiver of consent will be requested for deceased patients, as determined by local regulatory requirements.
Exclusion
- Secondary causes of LCAT deficiency
- Any other medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
Key Trial Info
Start Date :
August 12 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2028
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06217588
Start Date
August 12 2022
End Date
August 1 2028
Last Update
April 30 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104