Status:
NOT_YET_RECRUITING
Mecobalamin Combined With Ceftriaxone Sodium in the Treatment of Sepsis Liver Injury
Lead Sponsor:
Sichuan Provincial People's Hospital
Conditions:
Sepsis
Liver Dysfunction
Eligibility:
All Genders
18-85 years
Phase:
PHASE4
Brief Summary
The previous research of our research group shows that during the course of sepsis, the pyroptosis mediated by the caspase-4/GSDMD pathway in immune cells, induced by pathogens, is the main cause of i...
Detailed Description
1. Eligibility Criteria (1) Mild to moderate sepsis as defined by the △SOFA score; (2) Admission to ICU \<24 hours; (3) Serum total bile acid concentration TBA ≥10μmol/L, total bilirubin concentration...
Eligibility Criteria
Inclusion
- Mild to moderate sepsis as defined by the △SOFA score;
- Admission to ICU \<24 hours;
- Serum total bile acid concentration TBA ≥10μmol/L, total bilirubin concentration TBiL ≥17.1 μmol/L;
- Patients with suspected or confirmed infection as the main cause.-
Exclusion
- Age \>85 years or \<18 years;
- Patients contraindicated for mecobalamin treatment, allergic to ceftriaxone sodium, or other contraindications;
- Existence of a potential disease with a life expectancy of \<1 year;
- Patients with non-infectious causes such as burns, trauma, chemical poisoning;
- Withdrawal of life support or anticipated life-threatening condition within 48 hours;
- History of autoimmune diseases, tumors, hepatobiliary diseases, diabetes, metabolic genetic diseases;
- Vitamin B deficiency, malnutrition history;
- Re-admission to ICU within one year;
- Relatives or guardians unwilling to participate in the study;
- Pregnancy.-
Key Trial Info
Start Date :
January 15 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06220929
Start Date
January 15 2024
End Date
January 1 2025
Last Update
January 24 2024
Active Locations (1)
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1
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China