Status:
RECRUITING
Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation
Lead Sponsor:
Xijing Hospital of Digestive Diseases
Conditions:
Constipation - Functional
Refractory Constipation
Eligibility:
All Genders
18-45 years
Brief Summary
The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients. The main questions it aims to ans...
Eligibility Criteria
Inclusion
- 18≤ age ≤ 45 years old
- Right-handed
- Patients diagnosed as functional constipation according to the Rome IV criteria
- Informed consent of patients
Exclusion
- Complicated with gastrointestinal organic disease or significant functional abnormalities (tuberculosis, polyps, Crohn's disease, tumors, congenital megacolon, pelvic floor muscle relaxation, abnormal colonic transit test, etc.)
- Long-term intense exercise (continuous exercise for more than 8 hours per week, such as marathon runners or triathletes)
- No history of chronic pain, no recent major trauma
- Drug abuse or tobacco dependence (half a pack or more per day)
- Combined hypothyroidism and Parkinson's disease
- Patients with confirmed mental illness or neurological disorders who take psychotropic drugs, analgesics or hormones
- History of abdominal surgery (appendectomy, hysterectomy, or cholecystectomy)
- Contraindications to functional magnetic resonance imaging (claustrophobia, metal implants)
- Pregnant or lactating women with constipation after delivery
- Patients with other benign and malignant tumors and autoimmune diseases
- Infectious diseases such as hepatitis B, hepatitis C, AIDS, etc.
- Heart disease, organ failure and other chronic diseases that require long-term medication or affect the quality of life
Key Trial Info
Start Date :
November 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06221722
Start Date
November 1 2023
End Date
September 1 2026
Last Update
July 24 2025
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
People's Hospital of Ningxia Hui Autonomous Region
Yinchuan, Ningxia, China, 750002
2
Xi'an International Medical Center Hospital
Xi'an, Shaanxi, China, 710032
3
Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China, 710032