Status:

RECRUITING

Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients

Lead Sponsor:

Mỹ Đức Hospital

Conditions:

Adenomyosis

IVF

Eligibility:

FEMALE

18-42 years

Phase:

NA

Brief Summary

This randomized clinical trial aims to assess the comparative effectiveness of two distinct endometrial preparation protocols for frozen embryo transfer (FET) among women with adenomyosis undergoing I...

Detailed Description

* Adenomyosis is a benign gynecological disease in which the endometrial stroma invades the uterine myometrium. Adenomyosis affects approximately 10% of women of reproductive age. There are several hy...

Eligibility Criteria

Inclusion Criteria:

  • Confirm diagnosis with adenomyosis by using transvaginal ultrasonography (MUSA consensus) and/or pelvic magnetic resonance imaging.
  • Age between 18 - 42
  • Undergo less or equal to three previous IVF cycles
  • Indicate for frozen embryo transfer
  • Agree to have not more than two day-3 embryo or one blastocyst (day-5 and day-6) transferred
  • Not participating in any other study

Exclusion Criteria:

  • Embryos from IVM cycle
  • Having uterine or adnexal abnormalities (e.g., intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus; unremoved hydrosalpinx, endometrial polyp, submucosal leiomyoma, or leiomyoma with endometrial cavity distortion)
  • Having contraindications for exogenous hormones administration: breast cancer, risks of venous thromboembolism
  • Embryos from the oocyte donation cycle.
  • Patients with a history of GnRH injection within three months, measured from the last GnRHa injection to the study screening date.

Key Trial Info

Start Date :

February 19 2024

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

January 2 2027

Estimated Enrollment :

222 Patients enrolled

Trial Details

Trial ID

NCT06239376

Start Date

February 19 2024

End Date

January 2 2027

Last Update

March 20 2026

Active Locations (1)

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1

My Duc Hospital

Ho Chi Minh City, Ho Chi Minh City, Vietnam, 70000