Status:
RECRUITING
Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients
Lead Sponsor:
Mỹ Đức Hospital
Conditions:
Adenomyosis
IVF
Eligibility:
FEMALE
18-42 years
Phase:
NA
Brief Summary
This randomized clinical trial aims to assess the comparative effectiveness of two distinct endometrial preparation protocols for frozen embryo transfer (FET) among women with adenomyosis undergoing I...
Detailed Description
* Adenomyosis is a benign gynecological disease in which the endometrial stroma invades the uterine myometrium. Adenomyosis affects approximately 10% of women of reproductive age. There are several hy...
Eligibility Criteria
Inclusion Criteria:
- Confirm diagnosis with adenomyosis by using transvaginal ultrasonography (MUSA consensus) and/or pelvic magnetic resonance imaging.
- Age between 18 - 42
- Undergo less or equal to three previous IVF cycles
- Indicate for frozen embryo transfer
- Agree to have not more than two day-3 embryo or one blastocyst (day-5 and day-6) transferred
- Not participating in any other study
Exclusion Criteria:
- Embryos from IVM cycle
- Having uterine or adnexal abnormalities (e.g., intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus; unremoved hydrosalpinx, endometrial polyp, submucosal leiomyoma, or leiomyoma with endometrial cavity distortion)
- Having contraindications for exogenous hormones administration: breast cancer, risks of venous thromboembolism
- Embryos from the oocyte donation cycle.
- Patients with a history of GnRH injection within three months, measured from the last GnRHa injection to the study screening date.
Key Trial Info
Start Date :
February 19 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 2 2027
Estimated Enrollment :
222 Patients enrolled
Trial Details
Trial ID
NCT06239376
Start Date
February 19 2024
End Date
January 2 2027
Last Update
March 20 2026
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
My Duc Hospital
Ho Chi Minh City, Ho Chi Minh City, Vietnam, 70000