Status:
RECRUITING
Neurocognitive Impairment After Ischemic Stroke
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
Acute Ischemic Stroke
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
Affecting more than 150,000 patients in France, stroke is a major public health issue and a leading cause of disability worldwide. In western countries, 80-85% of strokes are of ischemic subtype. This...
Eligibility Criteria
Inclusion Criteria:
- Age: 18 to 45 years.
- Pathology: ischemic stroke diagnosed with brain MRI as per standard clinical practice, with or without occlusion of proximal artery, anterior or posterior circulation.
- Ability to understand and complete study tests and questionnaires: fluent French speaker and reader.
- All patients must be affiliated to a social security scheme.
- Signature of informed consent form.
Exclusion Criteria:
- Pre-existing cognitive impairment (defined as CQI <78 or clinical dementia).
- Severe functional dependence prior to stroke (defined as Modified Rankin Scale MRS = score 5).
- Any neurological or psychiatric comorbidity.
- Sensory disorders: visual impairment, blindness, deafness.
- Severe acquired phasic disorders: on the expressive oral side, in the presence of an inability to express oneself, which interferes with the collection of responses to neuropsychological tests; and on the receptive oral side, in the presence of an inability to understand the instructions of neuropsychological tests. Phasic functioning is systematically assessed during hospitalization by means of the NIHSS (score ≤ 2 on the "Language" sub-test), and will be rechecked clinically and psychometrically during neuropsychological assessments using the Language Screening Test (LAST) for both expression and oral comprehension. - Severe motor disorders: inability to mobilize the dominant upper limb for written neuropsychological tests.
- Contraindication to MRI.
- Pregnant women.
- HIV-positive patients: interaction of infectious pathology on cognitive functioning. Declarative, no HIV tests will be performed.
- Withdrawal of informed consent.
- Consumption of alcohol and/or narcotics on the day of neuropsychological assessments.
Key Trial Info
Start Date :
February 8 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 9 2027
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT06262529
Start Date
February 8 2024
End Date
May 9 2027
Last Update
March 20 2025
Active Locations (2)
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1
cannes Hospital
Cannes, France, 06600
2
Nice University Hospital
Nice, France, 06000