Status:

RECRUITING

Neurocognitive Impairment After Ischemic Stroke

Lead Sponsor:

Centre Hospitalier Universitaire de Nice

Conditions:

Acute Ischemic Stroke

Eligibility:

All Genders

18-45 years

Phase:

NA

Brief Summary

Affecting more than 150,000 patients in France, stroke is a major public health issue and a leading cause of disability worldwide. In western countries, 80-85% of strokes are of ischemic subtype. This...

Eligibility Criteria

Inclusion Criteria:

  • Age: 18 to 45 years.
  • Pathology: ischemic stroke diagnosed with brain MRI as per standard clinical practice, with or without occlusion of proximal artery, anterior or posterior circulation.
  • Ability to understand and complete study tests and questionnaires: fluent French speaker and reader.
  • All patients must be affiliated to a social security scheme.
  • Signature of informed consent form.

Exclusion Criteria:

  • Pre-existing cognitive impairment (defined as CQI <78 or clinical dementia).
  • Severe functional dependence prior to stroke (defined as Modified Rankin Scale MRS = score 5).
  • Any neurological or psychiatric comorbidity.
  • Sensory disorders: visual impairment, blindness, deafness.
  • Severe acquired phasic disorders: on the expressive oral side, in the presence of an inability to express oneself, which interferes with the collection of responses to neuropsychological tests; and on the receptive oral side, in the presence of an inability to understand the instructions of neuropsychological tests. Phasic functioning is systematically assessed during hospitalization by means of the NIHSS (score ≤ 2 on the "Language" sub-test), and will be rechecked clinically and psychometrically during neuropsychological assessments using the Language Screening Test (LAST) for both expression and oral comprehension. - Severe motor disorders: inability to mobilize the dominant upper limb for written neuropsychological tests.
  • Contraindication to MRI.
  • Pregnant women.
  • HIV-positive patients: interaction of infectious pathology on cognitive functioning. Declarative, no HIV tests will be performed.
  • Withdrawal of informed consent.
  • Consumption of alcohol and/or narcotics on the day of neuropsychological assessments.

Key Trial Info

Start Date :

February 8 2024

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

May 9 2027

Estimated Enrollment :

16 Patients enrolled

Trial Details

Trial ID

NCT06262529

Start Date

February 8 2024

End Date

May 9 2027

Last Update

March 20 2025

Active Locations (2)

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Page 1 of 1 (2 locations)

1

cannes Hospital

Cannes, France, 06600

2

Nice University Hospital

Nice, France, 06000