Efficacy and Safety of Baxdrostat in Participants with CKD and Uncontrolled Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial.
Jamie P Dwyer, Noha Maklad, Ola Vedin...
https://pubmed.ncbi.nlm.nih.gov/40913594Active, Not Recruiting
Phase 3
Age: 18Years +
All Genders
ID06268873
A Phase III, Randomised, Double-Blind Study to Assess the Efficacy, Safety and Tolerability of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on Chronic Kidney Disease (CKD) Progression in Participants With CKD and High Blood Pressure
Led by AstraZeneca · Updated on 2026-05-12
2554
Participants Needed
565
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to measure the efficacy and safety of baxdrostat/dapagliflozin in participants ≥ 18 years of age with CKD and HTN. This study consists of a screening, a 4-week dapagliflozin run-in period for participants untreated with SGLT2i at baseline; a 24-month double-blind period in which participants will receive either baxdrostat/dapagliflozin or placebo/dapagliflozin; and approximately 12-week open-label period in which all participants will discontinue baxdrostat/placebo and receive dapagliflozin alone. Site visits will take place at 2-, 4-, 8-, and 16- weeks following randomisation. Thereafter visits will occur approximately every 4 months, until the 24-month visit at which time baxdrostat/placebo will be discontinued. Participants will continue open-label dapagliflozin for another 12-weeks (approximately), where reassessment of eGFR will occur for the primary efficacy endpoint. In the event of premature discontinuation of blinded study intervention, participants will continue in the study and receive open-label dapagliflozin monotherapy, unless the participant meets dapagliflozin specific discontinuation criteria, in which case all study interventions will be discontinued.
CONDITIONS
Brief Title
A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
-
Participants of any sex and gender must be ≥ 18 years old, or older, at the time of signing the informed consent.
-
Participants with CKD and eGFR ≥ 30 and < 90 mL/min/1.73 m2 at screening
-
Urine albumin creatinine ratio > 200 mg/g (22.6 mg/mmol) and < 5000 mg/g (565 mg/mmol) at screening
-
Participants with history of HTN and a SBP ≥ 130 mmHg at screening and ≥ 120 mmHg at the randomisation visit
-
Stable and maximum tolerated dose of an ACE inhibitor or an ARB (not both) for at least 4 weeks prior to Screening Visit
-
Central laboratory serum potassium must meet the following criteria at the Screening Visit, based on screening eGFR:
- for participants with screening eGFR ≥ 45 mL/min/1.73 m2, potassium must be ≥ 3.0 and ≤ 4.8 mmol/L at the Screening Visit
- for participants with screening eGFR < 45 mL/min/1.73 m2, potassium must be ≥ 3.0 and ≤ 4.5 mmol/L at the Screening Visit
You will not qualify if you...
-
Systolic blood pressure > 180 mmHg, or DBP > 110 mmHg at screening.
-
Known hyperkalaemia, defined as potassium of ≥ 5.5 mmol/L within 3 months at screening.
-
Serum sodium < 135 mmol/L at the Screening Visit, determined as per central laboratory.
-
Diabetes mellitus:
(a) T1DM at Screening Visit: (i) For US only: patients with T1DM treated with SGLT2i for at least 4 months, without DKA during that period, and who have experience with ketone monitoring are eligible for inclusion.
(ii) For Japan only: patients with T1DM treated with dapagliflozin 10 mg for at least 4 months, without DKA during the period of dapagliflozin treatment are eligible for inclusion.
(b) Uncontrolled T2DM at screening: HbA1C > 10.5% (> 91 mmol/mol).
-
New York Heart Association functional HF class IV at screening.
-
Stroke, transient ischaemic cerebral attack, valve implantation or valve replacement, carotid surgery, or carotid angioplasty, acute coronary syndrome, or hospitalisation for worsening heart failure within previous 3 months prior to randomisation.
-
Any dialysis (including for acute kidney injury) within 3 months prior to Screening Visit.
-
Any acute kidney injury within 3 months prior to the Screening Visit
-
History of organ transplant or bone marrow transplant, or planned organ transplant within 6 months following randomisation (including kidney transplant).
-
History or ongoing allergy/hypersensitivity, as judged by the investigator, to SGLT2 inhibitor (eg, empagliflozin) or ASI.
-
Any clinical condition requiring systemic immunosuppression therapy other than stable maintenance therapy for at least 3 months prior to Visit 1.
-
Any use of mineralocorticoid receptor antagonists (such as spironolactone, eplerenone, or finerenone), potassium-sparing diuretics (such as triamterene or amiloride), or potassium binders (such as sodium zirconium cyclosilicate, patiromer, or sodium polystyrene sulfonate) within 4 weeks prior to screening.
Trial Site Locations
Total: 565 locations
1
Research Site
Fairhope, Alabama, United States, 36532
Status Unknown
2
Research Site
Phoenix, Arizona, United States, 85016
Status Unknown
3
Research Site
Surprise, Arizona, United States, 85374
Status Unknown
4
Research Site
Tucson, Arizona, United States, 85710
Status Unknown
5
Research Site
Searcy, Arkansas, United States, 72143
Status Unknown
6
Research Site
Beverly Hills, California, United States, 90211
Status Unknown
7
Research Site
Canyon Country, California, United States, 91351
Status Unknown
8
Research Site
Fremont, California, United States, 94538
Status Unknown
9
Research Site
Fullerton, California, United States, 92835
Status Unknown
10
Research Site
Lincoln, California, United States, 95648
Status Unknown
11
Research Site
Los Alamitos, California, United States, 90720
Status Unknown
12
Research Site
San Francisco, California, United States, 94110
Status Unknown
13
Research Site
Stanford, California, United States, 94305
Status Unknown
14
Research Site
Tarzana, California, United States, 91356
Status Unknown
15
Research Site
Arvada, Colorado, United States, 80002
Status Unknown
16
Research Site
Denver, Colorado, United States, 80220
Status Unknown
17
Research Site
New Britain, Connecticut, United States, 06051
Status Unknown
18
Research Site
Boca Raton, Florida, United States, 33487
Status Unknown
19
Research Site
Boynton Beach, Florida, United States, 33435
Status Unknown
20
Research Site
Edgewater, Florida, United States, 32132
Status Unknown
21
Research Site
Fort Lauderdale, Florida, United States, 33316
Status Unknown
22
Research Site
Hialeah, Florida, United States, 33012
Status Unknown
23
Research Site
Hollywood, Florida, United States, 33021
Status Unknown
24
Research Site
Jacksonville, Florida, United States, 32204
Status Unknown
25
Research Site
Jacksonville Beach, Florida, United States, 32250
Status Unknown
26
Research Site
Lake City, Florida, United States, 32055
Status Unknown
27
Research Site
Lake Worth, Florida, United States, 33467
Status Unknown
28
Research Site
Melbourne, Florida, United States, 32901
Status Unknown
29
Research Site
Miami, Florida, United States, 33165
Status Unknown
30
Research Site
Miami Lakes, Florida, United States, 33014
Status Unknown
31
Research Site
New Port Richey, Florida, United States, 34652
Status Unknown
32
Research Site
Ocoee, Florida, United States, 34761
Status Unknown
33
Research Site
Orlando, Florida, United States, 32806
Status Unknown
34
Research Site
Orlando, Florida, United States, 32808
Status Unknown
35
Research Site
Port Charlotte, Florida, United States, 33952
Status Unknown
36
Research Site
Port Orange, Florida, United States, 32127
Status Unknown
37
Research Site
Riverview, Florida, United States, 33578
Status Unknown
38
Research Site
Winter Haven, Florida, United States, 33880
Status Unknown
39
Research Site
Atlanta, Georgia, United States, 30344
Status Unknown
40
Research Site
Conyers, Georgia, United States, 30094
Status Unknown
41
Research Site
Macon, Georgia, United States, 31210
Status Unknown
42
Research Site
Champaign, Illinois, United States, 61822
Status Unknown
43
Research Site
Hazel Crest, Illinois, United States, 60429
Status Unknown
44
Research Site
Huntley, Illinois, United States, 60142
Status Unknown
45
Research Site
Rockford, Illinois, United States, 61107
Status Unknown
46
Research Site
Evansville, Indiana, United States, 47714
Status Unknown
47
Research Site
Fort Wayne, Indiana, United States, 46804
Status Unknown
48
Research Site
Hutchinson, Kansas, United States, 67502
Status Unknown
49
Research Site
Wichita, Kansas, United States, 67214
Status Unknown
50
Research Site
Bethesda, Maryland, United States, 20889
Status Unknown
51
Research Site
Lanham, Maryland, United States, 20706
Status Unknown
52
Research Site
Boston, Massachusetts, United States, 02114
Status Unknown
53
Research Site
Boston, Massachusetts, United States, 02115
Status Unknown
54
Research Site
New Bedford, Massachusetts, United States, 02740
Status Unknown
55
Research Site
Detroit, Michigan, United States, 48202
Status Unknown
56
Research Site
Pontiac, Michigan, United States, 48341
Status Unknown
57
Research Site
Saint Joseph, Michigan, United States, 49085
Status Unknown
58
Research Site
City of Saint Peters, Missouri, United States, 63376
Status Unknown
59
Research Site
Kansas City, Missouri, United States, 64111
Status Unknown
60
Research Site
Kansas City, Missouri, United States, 64128
Status Unknown
61
Research Site
Kansas City, Missouri, United States, 64151
Status Unknown
62
Research Site
St Louis, Missouri, United States, 63136
Status Unknown
63
Research Site
Eatontown, New Jersey, United States, 07724
Status Unknown
64
Research Site
Binghamton, New York, United States, 13905
Status Unknown
65
Research Site
Manhasset, New York, United States, 11030
Status Unknown
66
Research Site
Middletown, New York, United States, 10940
Status Unknown
67
Research Site
New York, New York, United States, 10016
Status Unknown
68
Research Site
Niagara Falls, New York, United States, 14304
Status Unknown
69
Research Site
Orchard Park, New York, United States, 14127
Status Unknown
70
Research Site
Rockville Centre, New York, United States, 11570
Status Unknown
71
Research Site
Greenville, North Carolina, United States, 27834
Status Unknown
72
Research Site
Jacksonville, North Carolina, United States, 28546
Status Unknown
73
Research Site
New Bern, North Carolina, United States, 28562
Status Unknown
74
Research Site
Statesville, North Carolina, United States, 28625
Status Unknown
75
Research Site
Wilmington, North Carolina, United States, 28401
Status Unknown
76
Research Site
Wilmington, North Carolina, United States, 28412
Status Unknown
77
Research Site
Columbus, Ohio, United States, 43213
Status Unknown
78
Research Site
Columbus, Ohio, United States, 43215
Status Unknown
79
Research Site
Maumee, Ohio, United States, 43537
Status Unknown
80
Research Site
Chester, Pennsylvania, United States, 19013
Status Unknown
81
Research Site
Langhorne, Pennsylvania, United States, 19047
Status Unknown
82
Research Site
Uniontown, Pennsylvania, United States, 15401
Status Unknown
83
Research Site
East Providence, Rhode Island, United States, 02914
Status Unknown
84
Research Site
East Providence, Rhode Island, United States, 02915
Status Unknown
85
Research Site
Providence, Rhode Island, United States, 02904
Status Unknown
86
Research Site
Charleston, South Carolina, United States, 29414
Status Unknown
87
Research Site
Columbia, South Carolina, United States, 29203
Status Unknown
88
Research Site
Sioux Falls, South Dakota, United States, 57104
Status Unknown
89
Research Site
Chattanooga, Tennessee, United States, 37421
Status Unknown
90
Research Site
Memphis, Tennessee, United States, 38105
Status Unknown
91
Research Site
Memphis, Tennessee, United States, 38115
Status Unknown
92
Research Site
Arlington, Texas, United States, 76015
Status Unknown
93
Research Site
Austin, Texas, United States, 78726
Status Unknown
94
Research Site
Austin, Texas, United States, 78751
Status Unknown
95
Research Site
Dallas, Texas, United States, 75230
Status Unknown
96
Research Site
Dallas, Texas, United States, 75246
Status Unknown
97
Research Site
Houston, Texas, United States, 77004
Status Unknown
98
Research Site
Houston, Texas, United States, 77040
Status Unknown
99
Research Site
Houston, Texas, United States, 77084
Status Unknown
100
Research Site
Houston, Texas, United States, 77099
Status Unknown
101
Research Site
Humble, Texas, United States, 77338
Status Unknown
102
Research Site
Lewisville, Texas, United States, 75057
Status Unknown
103
Research Site
Odessa, Texas, United States, 79761
Status Unknown
104
Research Site
Pasadena, Texas, United States, 77504
Status Unknown
105
Research Site
San Antonio, Texas, United States, 78212
Status Unknown
106
Research Site
San Antonio, Texas, United States, 78231
Status Unknown
107
Research Site
Salt Lake City, Utah, United States, 84132
Status Unknown
108
Research Site
South Salt Lake, Utah, United States, 84115
Status Unknown
109
Research Site
Burlington, Vermont, United States, 05401
Status Unknown
110
Research Site
Arlington, Virginia, United States, 22205
Status Unknown
111
Research Site
Manassas, Virginia, United States, 20110
Status Unknown
112
Research Site
Newport News, Virginia, United States, 23606
Status Unknown
113
Research Site
Salem, Virginia, United States, 24153
Status Unknown
114
Research Site
Woodbridge, Virginia, United States, 22192
Status Unknown
115
Research Site
Buenos Aires, Argentina, ARG 1425
Status Unknown
116
Research Site
CABA, Argentina, C1061
Status Unknown
117
Research Site
CABA, Argentina, C1120AAC
Status Unknown
118
Research Site
Ciudad Autonoma de Bs As, Argentina, C1013AAB
Status Unknown
119
Research Site
Ciudad de Buenos Aires, Argentina, C1019ABS
Status Unknown
120
Research Site
Córdoba, Argentina, X5006CBI
Status Unknown
121
Research Site
La Plata, Argentina, B1900AVG
Status Unknown
122
Research Site
Lanus, Argentina, 1824
Status Unknown
123
Research Site
Mar del Plata, Argentina, 7600
Status Unknown
124
Research Site
Mar del Plata, Argentina, B7600
Status Unknown
125
Research Site
Mendoza, Argentina, M5500
Status Unknown
126
Research Site
San Nicolás, Argentina, B2900DMH
Status Unknown
127
Research Site
Birtinya, Australia, 4575
Status Unknown
128
Research Site
Clayton, Australia, 3168
Status Unknown
129
Research Site
Darlinghurst, Australia, 2010
Status Unknown
130
Research Site
Gosford, Australia, 2250
Status Unknown
131
Research Site
Kogarah, Australia, 2217
Status Unknown
132
Research Site
Perth, Australia, 6000
Status Unknown
133
Research Site
St Leonards, Australia, 2065
Status Unknown
134
Research Site
Wollongong, Australia, 2500
Status Unknown
135
Research Site
Aalst, Belgium, 9300
Status Unknown
136
Research Site
Bonheiden, Belgium, 2820
Status Unknown
137
Research Site
Brussels, Belgium, 1200
Status Unknown
138
Research Site
Ghent, Belgium, 9000
Status Unknown
139
Research Site
Ieper, Belgium, 8900
Status Unknown
140
Research Site
Kortrijk, Belgium, 8500
Status Unknown
141
Research Site
Leuven, Belgium, 3000
Status Unknown
142
Research Site
Liège, Belgium, 4000
Status Unknown
143
Research Site
Roeselare, Belgium, 8800
Status Unknown
144
Research Site
Ronse, Belgium, 9600
Status Unknown
145
Research Site
Belém, Brazil, 66073-005
Status Unknown
146
Research Site
Campina Grande do Sul, Brazil, 83.430-000
Status Unknown
147
Research Site
Campinas, Brazil, 13060-080
Status Unknown
148
Research Site
Campinas, Brazil, 13060-904
Status Unknown
149
Research Site
Curitiba, Brazil, 80230-130
Status Unknown
150
Research Site
Curitiba, Brazil, 80440-020
Status Unknown
151
Research Site
Fortaleza, Brazil, 60175-047
Status Unknown
152
Research Site
Joinville, Brazil, 89227-680
Status Unknown
153
Research Site
Maringá, Brazil, 87060-040
Status Unknown
154
Research Site
Porto Alegre, Brazil, 90035-074
Status Unknown
155
Research Site
Porto Alegre, Brazil, 90160-093
Status Unknown
156
Research Site
São José do Rio Preto, Brazil, 15090-000
Status Unknown
157
Research Site
São Paulo, Brazil, 04012-180
Status Unknown
158
Research Site
São Paulo, Brazil, 04038-031
Status Unknown
159
Research Site
São Paulo, Brazil, 05403-9000
Status Unknown
160
Research Site
Dupnitsa, Bulgaria, 2600
Status Unknown
161
Research Site
Gotse Delchev, Bulgaria, 2900
Status Unknown
162
Research Site
Kozloduy, Bulgaria, 3320
Status Unknown
163
Research Site
Lom, Bulgaria, 3600
Status Unknown
164
Research Site
Pleven, Bulgaria, 5800
Status Unknown
165
Research Site
Plovdiv, Bulgaria, 4000
Status Unknown
166
Research Site
Plovdiv, Bulgaria, 4001
Status Unknown
167
Research Site
Plovdiv, Bulgaria, 4004
Status Unknown
168
Research Site
Sandanski, Bulgaria, 2800
Status Unknown
169
Research Site
Sliven, Bulgaria, 8800
Status Unknown
170
Research Site
Stara Zagora, Bulgaria, 6000
Status Unknown
171
Research Site
Veliko Tarnovo, Bulgaria, 5000
Status Unknown
172
Research Site
Yambol, Bulgaria, 8600
Status Unknown
173
Research Site
Edmonton, Alberta, Canada, T6G 2G3
Status Unknown
174
Research Site
Vancouver, British Columbia, Canada, V5Y 3W2
Status Unknown
175
Research Site
Winnipeg, Manitoba, Canada, R2V 3M3
Status Unknown
176
Research Site
Halifax, Nova Scotia, Canada, B3H 1V7
Status Unknown
177
Research Site
Sydney, Nova Scotia, Canada, B1P 1P3
Status Unknown
178
Research Site
Brampton, Ontario, Canada, L6S 0C6
Status Unknown
179
Research Site
Concord, Ontario, Canada, L4K 4M2
Status Unknown
180
Research Site
London, Ontario, Canada, N6A 5A5
Status Unknown
181
Research Site
Oshawa, Ontario, Canada, L1G 2B9
Status Unknown
182
Research Site
Stoney Creek, Ontario, Canada, L8J 3W2
Status Unknown
183
Research Site
Toronto, Ontario, Canada, M4G 3E8
Status Unknown
184
Research Site
Toronto, Ontario, Canada, M5C 2T2
Status Unknown
185
Research Site
Waterloo, Ontario, Canada, N2T 0C1
Status Unknown
186
Research Site
Laval, Quebec, Canada, H7T 2P5
Status Unknown
187
Research Site
Montreal, Quebec, Canada, H2X 0A9
Status Unknown
188
Research Site
Montreal, Quebec, Canada, H4J 1C5
Status Unknown
189
Research Site
Québec, Quebec, Canada, G1R 2J6
Status Unknown
190
Research Site
Sherbrooke, Quebec, Canada, J1H 5N4
Status Unknown
191
Research Site
Saint John, Canada, E2L 4L2
Status Unknown
192
Research Site
Araucania, Chile, 4781151
Status Unknown
193
Research Site
Santiago, Chile, 7500922
Status Unknown
194
Research Site
Valdivia, Chile, 5090000
Status Unknown
195
Research Site
Victoria, Chile, 4720097
Status Unknown
196
Research Site
Baotou, China, 014010
Status Unknown
197
Research Site
Beijing, China, 100029
Status Unknown
198
Research Site
Beijing, China, 100034
Status Unknown
199
Research Site
Beijing, China, 100035
Status Unknown
200
Research Site
Beijing, China, 100191
Status Unknown
201
Research Site
Beijing, China, 102218
Status Unknown
202
Research Site
Changchun, China, 130041
Status Unknown
203
Research Site
Changsha, China, 410013
Status Unknown
204
Research Site
Changzhou, China, 272100
Status Unknown
205
Research Site
Chengdu, China, 610072
Status Unknown
206
Research Site
Chongqing, China, 402260
Status Unknown
207
Research Site
Dongguan, China, 523009
Status Unknown
208
Research Site
Foshan, China, 528000
Status Unknown
209
Research Site
Guangzhou, China, 510630
Status Unknown
210
Research Site
Guangzhou, China, 510800
Status Unknown
211
Research Site
Guiyang, China, 550044
Status Unknown
212
Research Site
Haikou, China, 570311
Status Unknown
213
Research Site
Hangzhou, China, 310014
Status Unknown
214
Research Site
Hengyang, China, 421001
Status Unknown
215
Research Site
Huai'an, China, 223300
Status Unknown
216
Research Site
Lanzhou, China, 730000
Status Unknown
217
Research Site
Nanchang, China, 330008
Status Unknown
218
Research Site
Nanjing, China, 210009
Status Unknown
219
Research Site
Ningbo, China, 315010
Status Unknown
220
Research Site
Panjin, China, 124009
Status Unknown
221
Research Site
Pingxiang, China, 337055
Status Unknown
222
Research Site
Sanya, China, 572000
Status Unknown
223
Research Site
Shanghai, China, 200240
Status Unknown
224
Research Site
Shenyang, China, 110004
Status Unknown
225
Research Site
Shenzhen, China, 518036
Status Unknown
226
Research Site
Ürümqi, China, 831118
Status Unknown
227
Research Site
Wuhan, China, 430010
Status Unknown
228
Research Site
Wuhan, China, 430060
Status Unknown
229
Research Site
Wuxi, China, 214023
Status Unknown
230
Research Site
Xi'an, China, 710061
Status Unknown
231
Research Site
Xiamen, China, 361004
Status Unknown
232
Research Site
Yantai, China, 264000
Status Unknown
233
Research Site
Yinchuan, China, 750004
Status Unknown
234
Research Site
Zhengzhou, China, 450052
Status Unknown
235
Research Site
Frýdek-Místek, Czechia, 738 01
Status Unknown
236
Research Site
Jilemnice, Czechia, 514 01
Status Unknown
237
Research Site
Krnov, Czechia, 794 01
Status Unknown
238
Research Site
Náchod, Czechia, 547 01
Status Unknown
239
Research Site
Olomouc, Czechia, 772 00
Status Unknown
240
Research Site
Police nad Metují, Czechia, 549 54
Status Unknown
241
Research Site
Prague, Czechia, 104 00
Status Unknown
242
Research Site
Prague, Czechia, 140 00
Status Unknown
243
Research Site
Prague, Czechia, 160 00
Status Unknown
244
Research Site
Třebíč, Czechia, 674 01
Status Unknown
245
Research Site
Aalborg, Denmark, 9000
Status Unknown
246
Research Site
Aarhus, Denmark, 8200
Status Unknown
247
Research Site
Copenhagen E, Denmark, 2100
Status Unknown
248
Research Site
Esbjerg, Denmark, 6700
Status Unknown
249
Research Site
Herlev, Denmark, 2730
Status Unknown
250
Research Site
Herning, Denmark, 7400
Status Unknown
251
Research Site
Holbæk, Denmark, 4300
Status Unknown
252
Research Site
Amiens, France, 80054
Status Unknown
253
Research Site
Annonay, France, 07103
Status Unknown
254
Research Site
Bois-Guillaume, France, 76230
Status Unknown
255
Research Site
Bordeaux, France, 33076
Status Unknown
256
Research Site
Boulogne-Billancourt, France, 92104
Status Unknown
257
Research Site
Brest, France, 29200
Status Unknown
258
Research Site
Clermont-Ferrand, France, 63003
Status Unknown
259
Research Site
La Roche-sur-Yon, France, 85925
Status Unknown
260
Research Site
Le Puy-en-Velay, France, 43000
Status Unknown
261
Research Site
Lille, France, 59037
Status Unknown
262
Research Site
Marseille, France, 13385
Status Unknown
263
Research Site
Nîmes, France, 30029
Status Unknown
264
Research Site
Paris, France, 75015
Status Unknown
265
Research Site
Paris, France, 75020
Status Unknown
266
Research Site
Poitiers, France, 86021
Status Unknown
267
Research Site
Quimper, France, 29000
Status Unknown
268
Research Site
Sarcelles, France, 95200
Status Unknown
269
Research Site
Toulouse, France, 31400
Status Unknown
270
Research Site
Tours, France, 37000
Status Unknown
271
Research Site
Valenciennes, France, 59300
Status Unknown
272
Research Site
Vandœuvre-lès-Nancy, France, 54511
Status Unknown
273
Research Site
Aachen, Germany, 52074
Status Unknown
274
Research Site
Amberg, Germany, 92224
Status Unknown
275
Research Site
Bad Oeynhausen, Germany, 32545
Status Unknown
276
Research Site
Berlin, Germany, 12203
Status Unknown
277
Research Site
Berlin, Germany, 13187
Status Unknown
278
Research Site
Berlin, Germany, 13353
Status Unknown
279
Research Site
Bochum, Germany, 44787
Status Unknown
280
Research Site
Dresden, Germany, 1307
Status Unknown
281
Research Site
Essen, Germany, 45355
Status Unknown
282
Research Site
Falkensee, Germany, 14612
Status Unknown
283
Research Site
Hamburg, Germany, 22607
Status Unknown
284
Research Site
Herne, Germany, 44625
Status Unknown
285
Research Site
Leipzig, Germany, 04179
Status Unknown
286
Research Site
Mainz, Germany, 55131
Status Unknown
287
Research Site
München, Germany, 81675
Status Unknown
288
Research Site
Münster, Germany, 48145
Status Unknown
289
Research Site
Nuremberg, Germany, 90443
Status Unknown
290
Research Site
Oldenburg, Germany, 23758
Status Unknown
291
Research Site
Reinfeld (Holstein), Germany, 23858
Status Unknown
292
Research Site
Ulm, Germany, 89081
Status Unknown
293
Research Site
Völklingen, Germany, 66333
Status Unknown
294
Research Site
Alexandroupoli, Greece, 68100
Status Unknown
295
Research Site
Athens, Greece, 11527
Status Unknown
296
Research Site
Heraklion, Greece, 71500
Status Unknown
297
Research Site
Ioannina, Greece, 45500
Status Unknown
298
Research Site
Pátrai, Greece, 26504
Status Unknown
299
Research Site
Thessaloniki, Greece, 54636
Status Unknown
300
Research Site
Thessaloniki, Greece, 54642
Status Unknown
301
Research Site
Békéscsaba, Hungary, 5600
Status Unknown
302
Research Site
Budapest, Hungary, 1036
Status Unknown
303
Research Site
Budapest, Hungary, 1132
Status Unknown
304
Research Site
Kecskemét, Hungary, 6000
Status Unknown
305
Research Site
Nyíregyháza, Hungary, 4400
Status Unknown
306
Research Site
Pécs, Hungary, 7624
Status Unknown
307
Research Site
Pécs, Hungary, 7635
Status Unknown
308
Research Site
Siófok, Hungary, 8600
Status Unknown
309
Research Site
Székesfehérvár, Hungary, 8000
Status Unknown
310
Research Site
Bangalore, India, 560 092
Status Unknown
311
Research Site
Belagavi, India, 590010
Status Unknown
312
Research Site
Calicut, India, 673 008
Status Unknown
313
Research Site
Chennai, India, 600037
Status Unknown
314
Research Site
Coimbatore, India, 641018
Status Unknown
315
Research Site
Dehradun, India, 248001
Status Unknown
316
Research Site
Hyderabad, India, 500038
Status Unknown
317
Research Site
Kolkata, India, 700020
Status Unknown
318
Research Site
Madurai, India, 625107
Status Unknown
319
Research Site
New Delhi, India, 110017
Status Unknown
320
Research Site
New Delhi, India, 110029
Status Unknown
321
Research Site
Pune, India, 411013
Status Unknown
322
Research Site
Vijayawada, India, 520 008
Status Unknown
323
Research Site
Ashkelon, Israel, 78278
Status Unknown
324
Research Site
Haifa, Israel, 34362
Status Unknown
325
Research Site
Jerusalem, Israel, 9372212
Status Unknown
326
Research Site
Kfar Saba, Israel, 44410
Status Unknown
327
Research Site
Petah Tikva, Israel, 49372
Status Unknown
328
Research Site
Ramat Gan, Israel, 52621
Status Unknown
329
Research Site
Rehovot, Israel, 76100
Status Unknown
330
Research Site
Tel Aviv, Israel, 6423906
Status Unknown
331
Research Site
Bologna, Italy, 40138
Status Unknown
332
Research Site
Catanzaro, Italy, 88100
Status Unknown
333
Research Site
Chiavari, Italy, 16034
Status Unknown
334
Research Site
Desio, Italy, 20832
Status Unknown
335
Research Site
Milan, Italy, 20142
Status Unknown
336
Research Site
Naples, Italy, 80131
Status Unknown
337
Research Site
Parma, Italy, 43126
Status Unknown
338
Research Site
Rozzano, Italy, 20089
Status Unknown
339
Research Site
San Giovanni Rotondo, Italy, 71013
Status Unknown
340
Research Site
Torino, Italy, 10126
Status Unknown
341
Research Site
Chūōku, Japan, 103-0002
Status Unknown
342
Research Site
Chūōku, Japan, 103-0027
Status Unknown
343
Research Site
Chūōku, Japan, 103-0028
Status Unknown
344
Research Site
Daito-shi, Japan, 574-0074
Status Unknown
345
Research Site
Fujisawa-shi, Japan, 251-8550
Status Unknown
346
Research Site
Fukuoka, Japan, 815-8555
Status Unknown
347
Research Site
Hiroshima, Japan, 730-8518
Status Unknown
348
Research Site
Hiroshima, Japan, 732-0057
Status Unknown
349
Research Site
Ina-shi, Japan, 396-8555
Status Unknown
350
Research Site
Kamakura-shi, Japan, 247-0056
Status Unknown
351
Research Site
Kamakura-shi, Japan, 247-8533
Status Unknown
352
Research Site
Kasugai-shi, Japan, 486-8510
Status Unknown
353
Research Site
Kawaguchi, Japan, 332-0015
Status Unknown
354
Research Site
Kofu, Japan, 400-8506
Status Unknown
355
Research Site
Kumagaya-shi, Japan, 360-0197
Status Unknown
356
Research Site
Kurume-shi, Japan, 830-0011
Status Unknown
357
Research Site
Kyoto, Japan, 606-8507
Status Unknown
358
Research Site
Marugame-shi, Japan, 763-8502
Status Unknown
359
Research Site
Matsuyama, Japan, 790-0024
Status Unknown
360
Research Site
Nagoya, Japan, 457-8511
Status Unknown
361
Research Site
Naka, Japan, 311-0113
Status Unknown
362
Research Site
Nishinomiya-Shi, Japan, 662-0918
Status Unknown
363
Research Site
Obihiro-shi, Japan, 080-0848
Status Unknown
364
Research Site
Osaka, Japan, 553-0003
Status Unknown
365
Research Site
Ōita, Japan, 870-0033
Status Unknown
366
Research Site
Sakaishi, Japan, 593-8304
Status Unknown
367
Research Site
Sapporo, Japan, 064-8570
Status Unknown
368
Research Site
Sendai, Japan, 980-8574
Status Unknown
369
Research Site
Shinjyuku-ku, Japan, 160-0022
Status Unknown
370
Research Site
Shizuoka, Japan, 421-0117
Status Unknown
371
Research Site
Takatsuki-shi, Japan, 569-8686
Status Unknown
372
Research Site
Toride-shi, Japan, 302-0022
Status Unknown
373
Research Site
Toyota-Shi, Japan, 471-8513
Status Unknown
374
Research Site
Tsu, Japan, 514-1101
Status Unknown
375
Research Site
Tsu, Japan, 514-8507
Status Unknown
376
Research Site
Ueda-shi, Japan, 386-8610
Status Unknown
377
Research Site
Urayasu, Japan, 279-0001
Status Unknown
378
Research Site
Yaizu-shi, Japan, 425-8505
Status Unknown
379
Research Site
Yokohama, Japan, 236-0004
Status Unknown
380
Research Site
Klang, Malaysia, 41200
Status Unknown
381
Research Site
Kota Kinabalu, Malaysia, 88200
Status Unknown
382
Research Site
Kuala Lumpur, Malaysia, 50586
Status Unknown
383
Research Site
Kuala Lumpur, Malaysia, 59100
Status Unknown
384
Research Site
Kuantan, Malaysia, 25200
Status Unknown
385
Research Site
Seremban, Malaysia, 70300
Status Unknown
386
Research Site
Taiping, Malaysia, 34000
Status Unknown
387
Research Site
Alkmaar, Netherlands, 1815 JD
Status Unknown
388
Research Site
Amersfoort, Netherlands, 3813 TZ
Status Unknown
389
Research Site
Dordrecht, Netherlands, 3318 AT
Status Unknown
390
Research Site
Hardenberg, Netherlands, 7772 SE
Status Unknown
391
Research Site
Harderwijk, Netherlands, 3844 DG
Status Unknown
392
Research Site
Hilversum, Netherlands, 1212 VG
Status Unknown
393
Research Site
Utrecht, Netherlands, 3584 CX
Status Unknown
394
Research Site
Arequipa, Peru, AREQUIPA01
Status Unknown
395
Research Site
Chorrillos, Peru, Lima 9
Status Unknown
396
Research Site
Lima, Peru, 15036
Status Unknown
397
Research Site
Lima, Peru, 15046
Status Unknown
398
Research Site
Lima, Peru, 15088
Status Unknown
399
Research Site
Lima, Peru, LIMA 01
Status Unknown
400
Research Site
Piura, Peru, 20001
Status Unknown
401
Research Site
Cebu City, Philippines, 6000
Status Unknown
402
Research Site
Davao City, Philippines, PH-8000
Status Unknown
403
Research Site
Iloilo City, Philippines, 5000
Status Unknown
404
Research Site
Laguna, Philippines, 4024
Status Unknown
405
Research Site
Manila, Philippines, 1000
Status Unknown
406
Research Site
Quezon City, Philippines, 1101
Status Unknown
407
Research Site
Chrzanów, Poland, 32-500
Status Unknown
408
Research Site
Gdynia, Poland, 81-157
Status Unknown
409
Research Site
Krakow, Poland, 30-688
Status Unknown
410
Research Site
Krakow, Poland, 31-156
Status Unknown
411
Research Site
Krakow, Poland, 31-261
Status Unknown
412
Research Site
Krakow, Poland, 31-513
Status Unknown
413
Research Site
Krakow, Poland, 31-801
Status Unknown
414
Research Site
Lodz, Poland, 90-549
Status Unknown
415
Research Site
Lodz, Poland, 91-211
Status Unknown
416
Research Site
Lodz, Poland, 91-363
Status Unknown
417
Research Site
Lodz, Poland, 92-213
Status Unknown
418
Research Site
Lublin, Poland, 20-090
Status Unknown
419
Research Site
Olsztyn, Poland, 10-165
Status Unknown
420
Research Site
Poznan, Poland, 60-355
Status Unknown
421
Research Site
Poznan, Poland, 61-848
Status Unknown
422
Research Site
Rzeszów, Poland, 35-055
Status Unknown
423
Research Site
Szczecin, Poland, 70-111
Status Unknown
424
Research Site
Tczew, Poland, 83-110
Status Unknown
425
Research Site
Warsaw, Poland, 03-291
Status Unknown
426
Research Site
Wroclaw, Poland, 50-381
Status Unknown
427
Research Site
Wroclaw, Poland, 50-981
Status Unknown
428
Research Site
Wroclaw, Poland, 53-673
Status Unknown
429
Research Site
Żywiec, Poland, 34-300
Status Unknown
430
Research Site
Bucharest, Romania, 010731
Status Unknown
431
Research Site
Bucharest, Romania, 014461
Status Unknown
432
Research Site
Bucharest, Romania, 022328
Status Unknown
433
Research Site
Bucharest, Romania, 040883
Status Unknown
434
Research Site
Cluj-Napoca, Romania, 400347
Status Unknown
435
Research Site
Iași, Romania, 700503
Status Unknown
436
Research Site
Oradea, Romania, 410469
Status Unknown
437
Research Site
Târgu Mureş, Romania, 540136
Status Unknown
438
Research Site
Timișoara, Romania, 300723
Status Unknown
439
Research Site
Dammam, Saudi Arabia, 31444
Status Unknown
440
Research Site
Riyadh, Saudi Arabia, 11426
Status Unknown
441
Research Site
Riyadh, Saudi Arabia, 11462
Status Unknown
442
Research Site
Riyadh, Saudi Arabia, 11525
Status Unknown
443
Research Site
Riyadh, Saudi Arabia, 12713
Status Unknown
444
Research Site
Belgrade, Serbia, 11000
Status Unknown
445
Research Site
Belgrade, Serbia, 11120
Status Unknown
446
Research Site
Kragujevac, Serbia, 34000
Status Unknown
447
Research Site
Niš, Serbia, 18000
Status Unknown
448
Research Site
Novi Sad, Serbia, 21000
Status Unknown
449
Research Site
Banská Bystrica, Slovakia, 974 01
Status Unknown
450
Research Site
Lučenec, Slovakia, 984 01
Status Unknown
451
Research Site
Martin, Slovakia, 03659
Status Unknown
452
Research Site
Myjava, Slovakia, 90701
Status Unknown
453
Research Site
Nitra, Slovakia, 949 01
Status Unknown
454
Research Site
Nitra, Slovakia, 949 11
Status Unknown
455
Research Site
Prešov, Slovakia, 080 01
Status Unknown
456
Research Site
Púchov, Slovakia, 020 01
Status Unknown
457
Research Site
Rožňava, Slovakia, 048 01
Status Unknown
458
Research Site
Trnava, Slovakia, 91708
Status Unknown
459
Research Site
Žilina, Slovakia, 010 01
Status Unknown
460
Research Site
Benoni, South Africa, 1501
Status Unknown
461
Research Site
Cape Town, South Africa, 7570
Status Unknown
462
Research Site
Cape Town, South Africa, 7925
Status Unknown
463
Research Site
Durban, South Africa, 4091
Status Unknown
464
Research Site
KwaDukuza, South Africa, 4450
Status Unknown
465
Research Site
Lenasia, South Africa, 1827
Status Unknown
466
Research Site
Midrand, South Africa, 1685
Status Unknown
467
Research Site
Newton, South Africa, 2113
Status Unknown
468
Research Site
Parow, South Africa, 7505
Status Unknown
469
Research Site
Ansan-si, South Korea, 15355
Status Unknown
470
Research Site
Anyang-si, South Korea, 14068
Status Unknown
471
Research Site
Busan, South Korea, 49241
Status Unknown
472
Research Site
Cheonan-si, South Korea, 31151
Status Unknown
473
Research Site
Daejeon, South Korea, 301-723
Status Unknown
474
Research Site
Goyang-si, South Korea, 10380
Status Unknown
475
Research Site
Gwangju, South Korea, 61469
Status Unknown
476
Research Site
Seoul, South Korea, 03181
Status Unknown
477
Research Site
Seoul, South Korea, 03312
Status Unknown
478
Research Site
Seoul, South Korea, 03722
Status Unknown
479
Research Site
Seoul, South Korea, 04401
Status Unknown
480
Research Site
Seoul, South Korea, 06273
Status Unknown
481
Research Site
Seoul, South Korea, 07061
Status Unknown
482
Research Site
Uijeongbu-si, South Korea, 11765
Status Unknown
483
Research Site
Wŏnju, South Korea, 26426
Status Unknown
484
Research Site
Yangsan, South Korea, 50612
Status Unknown
485
Research Site
A Coruña, Spain, 15006
Status Unknown
486
Research Site
Almería, Spain, 4009
Status Unknown
487
Research Site
Badalona, Spain, 08916
Status Unknown
488
Research Site
L'Hospitalet de Llobregat, Spain, 08907
Status Unknown
489
Research Site
Lugo, Spain, 27004
Status Unknown
490
Research Site
Madrid, Spain, 28040
Status Unknown
491
Research Site
Málaga, Spain, 29010
Status Unknown
492
Research Site
Palma deMallorca, Spain, 07010
Status Unknown
493
Research Site
Pamplona, Spain, 31008
Status Unknown
494
Research Site
Seville, Spain, 41950
Status Unknown
495
Research Site
Valencia, Spain, 46010
Status Unknown
496
Research Site
Gävle, Sweden, 80188
Status Unknown
497
Research Site
Gothenburg, Sweden, 413 46
Status Unknown
498
Research Site
Linköping, Sweden, 58185
Status Unknown
499
Research Site
Rättvik, Sweden, 79530
Status Unknown
500
Research Site
Stockholm, Sweden, 141 86
Status Unknown
501
Research Site
Stockholm, Sweden, 18288
Status Unknown
502
Research Site
Uppsala, Sweden, 751 85
Status Unknown
503
Research Site
Kaohsiung City, Taiwan, 80756
Status Unknown
504
Research Site
Kaohsiung City, Taiwan, 81362
Status Unknown
505
Research Site
New Taipei City, Taiwan, 220
Status Unknown
506
Research Site
Taichung, Taiwan, 402
Status Unknown
507
Research Site
Taichung, Taiwan, 40447
Status Unknown
508
Research Site
Taichung, Taiwan, 433004
Status Unknown
509
Research Site
Taipei, Taiwan, 10002
Status Unknown
510
Research Site
Taipei, Taiwan, 110
Status Unknown
511
Research Site
Taipei, Taiwan, 112
Status Unknown
512
Research Site
Taoyuan, Taiwan, 33305
Status Unknown
513
Research Site
Yung Kang City, Taiwan, 71044
Status Unknown
514
Research Site
Bangkok, Thailand, 10330
Status Unknown
515
Research Site
Bangkok, Thailand, 10700
Status Unknown
516
Research Site
Chiang Mai, Thailand, 50200
Status Unknown
517
Research Site
Hat Yai, Thailand, 90110
Status Unknown
518
Research Site
Muang, Thailand, 40002
Status Unknown
519
Research Site
Phutthamonthon, Thailand, 73170
Status Unknown
520
Research Site
Ratchathewi, Thailand, 10400
Status Unknown
521
Research Site
Ubonratchathani, Thailand, 34000
Status Unknown
522
Research Site
Adana, Turkey (Türkiye), 01060
Status Unknown
523
Research Site
Adapazarı, Turkey (Türkiye), 54100
Status Unknown
524
Research Site
Afyonkarahisar, Turkey (Türkiye), 03030
Status Unknown
525
Research Site
Ankara, Turkey (Türkiye), 06230
Status Unknown
526
Research Site
Antalya, Turkey (Türkiye), 07059
Status Unknown
527
Research Site
Bursa, Turkey (Türkiye), 16059
Status Unknown
528
Research Site
Istanbul, Turkey (Türkiye), 34890
Status Unknown
529
Research Site
Kahramanmaraş, Turkey (Türkiye), 46100
Status Unknown
530
Research Site
Kayseri, Turkey (Türkiye), 38039
Status Unknown
531
Research Site
Kocaeli, Turkey (Türkiye), 41380
Status Unknown
532
Research Site
Chernivtsі, Ukraine, 58002
Status Unknown
533
Research Site
Ivano-Frankivsk, Ukraine, 76000
Status Unknown
534
Research Site
Kyiv, Ukraine, 01601
Status Unknown
535
Research Site
Kyiv, Ukraine, 02081
Status Unknown
536
Research Site
Kyiv, Ukraine, 03037
Status Unknown
537
Research Site
Kyiv, Ukraine, 03057
Status Unknown
538
Research Site
Kyiv, Ukraine, 04050
Status Unknown
539
Research Site
Ternopil, Ukraine, 46000
Status Unknown
540
Research Site
Ternopil, Ukraine, 46001
Status Unknown
541
Research Site
Uzhhorod, Ukraine, 88018
Status Unknown
542
Research Site
Vinnytsia, Ukraine, 21001
Status Unknown
543
Research Site
Vinnytsia, Ukraine, 21009
Status Unknown
544
Research Site
Vinnytsia, Ukraine, 21018
Status Unknown
545
Research Site
Vinnytsia, Ukraine, 21029
Status Unknown
546
Research Site
Bristol, United Kingdom, BS105NB
Status Unknown
547
Research Site
Cambridge, United Kingdom, CB2 0XY
Status Unknown
548
Research Site
Dundee, United Kingdom, DD1 9SY
Status Unknown
549
Research Site
Glasgow, United Kingdom, G51 4TF
Status Unknown
550
Research Site
Harrow, United Kingdom, HA3 7LT
Status Unknown
551
Research Site
Hounslow, United Kingdom, TW4 7NR
Status Unknown
552
Research Site
Leicester, United Kingdom, Le5 4PW
Status Unknown
553
Research Site
Liverpool, United Kingdom, L9 7AL
Status Unknown
554
Research Site
London, United Kingdom, EC1A 2BE
Status Unknown
555
Research Site
London, United Kingdom, SE5 9RJ
Status Unknown
556
Research Site
Newcastle-under-Lyme, United Kingdom, ST4 6QG
Status Unknown
557
Research Site
Nottingham, United Kingdom, NG5 1PB
Status Unknown
558
Research Site
Wolverhampton, United Kingdom, WV10 0QP
Status Unknown
559
Research Site
Can Tho, Vietnam, 900000
Status Unknown
560
Research Site
Can Tho, Vietnam, 920000
Status Unknown
561
Research Site
Da Nang, Vietnam, 550000
Status Unknown
562
Research Site
Haiphong, Vietnam, 180000
Status Unknown
563
Research Site
Ho Chi Minh City, Vietnam, 700000
Status Unknown
564
Research Site
Ho Chi Minh City, Vietnam, 70000
Status Unknown
565
Research Site
Hochiminh City, Vietnam, 700000
Status Unknown
Loading map...
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here