Status:

RECRUITING

68Ga-TCR-FAPI PET/CT Guided Precision Surgery for MTC

Lead Sponsor:

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Collaborating Sponsors:

Peking University

Peking University Cancer Hospital & Institute

Conditions:

Medullary Thyroid Cancer

Prositron Emission Tomography

Eligibility:

All Genders

18-75 years

Phase:

NA

Brief Summary

This is a phase II clinical trial to evaluate the capability of 68Ga-labeled targeted covalent radiopharmaceutical (TCR) fibroblast activation protein inhibitor (FAPI) PET/CT to guide the surgical tre...

Detailed Description

Surgery remains the only curative option for MTC, yet the current imaging-based method (ultrasound, CT, MRI, 18F-FDG PET/CT) or calcitonin-based method are insufficient to map the extent of disease. I...

Eligibility Criteria

Inclusion Criteria:

  • Age between 18 and 75 years;
  • Diagnosed with MTC and have surgical indication based on preliminary evaluation; the tumor may be newly diagnosed or previously treated;
  • Expected survival of at least 12 weeks;
  • No major organ dysfunction (heart, lung, liver, kidney and other major organ include), acute or life-threatening status of infection;
  • Be willing and able to understand the research content and provide written informed consent/assent for the trial.

Exclusion Criteria:

  • Have a history of imaging agent allergies;
  • Does not meet the PET-CT scan sedation requirements, or has contraindications for PET-CT examination;
  • Be pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial;
  • No surgical indication (i.e., no measurable disease, unresectable disease, or significant present of distant metastasis), refusing surgery or 68Ga-TCR-FAPI PET/CT-guided surgery.

Key Trial Info

Start Date :

October 1 2023

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 31 2027

Estimated Enrollment :

50 Patients enrolled

Trial Details

Trial ID

NCT06277180

Start Date

October 1 2023

End Date

December 31 2027

Last Update

February 26 2024

Active Locations (1)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 1 (1 locations)

1

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Beijing, China, 100021

68Ga-TCR-FAPI PET/CT Guided Precision Surgery for MTC | DecenTrialz