Status:

RECRUITING

A Home-based Exercise and Physical Activity Intervention After Liver Transplantation: Impact of Exercise Intensity

Lead Sponsor:

Universitaire Ziekenhuizen KU Leuven

Collaborating Sponsors:

KU Leuven

Conditions:

Liver Transplantation

Physical Fitness

Eligibility:

All Genders

18+ years

Phase:

NA

Brief Summary

Research demonstrated that transplant recipients benefit from physical activity, but there is a gap in knowledge regarding the required intensity. In the PHOENIX-Liver study, researchers aim to invest...

Detailed Description

Liver transplantation constitutes the only curative treatment for patients with end-stage liver disease. Advances in the field have led to favourable short- and medium term (1-3 year) post-transplant ...

Eligibility Criteria

Inclusion Criteria:

  • de novo adult liver transplant recipients with a transplant vintage of two to three months
  • access to a home freezer (± -18°C)

Exclusion Criteria:

  • Aberrant CPET (abnormal low cardiorespiratory fitness is not considered an exclusion criteria), unstable angina, life-threatening arrhythmias, uncontrolled hypertension/diabetes, HbA1c ≥ 9%, severe pulmonary disease (FEV1 < 50%), musculoskeletal disorders not allowing physical training on a cycle ergometer, or any other medical reasons by the physician considered to be a contraindication for moderate or high-intensity physical exercise
  • multi-organ transplantation (exception: combined liver-kidney transplant is considered eligible for participation)
  • ongoing treatment for malignancies
  • unable to understand Dutch
  • no access to smartphone and/or computer with internet access
  • does not willing to except the general conditions of Coachbox. Preparticipation medical screening (cardiopulmonary exercise testing with 12-lead ECG + stratification of cardiovascular risk factors) will be performed by a cardiologist (Dr. Kaatje Goetschalckx at UZ Leuven).

Key Trial Info

Start Date :

March 1 2023

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 1 2026

Estimated Enrollment :

147 Patients enrolled

Trial Details

Trial ID

NCT06302205

Start Date

March 1 2023

End Date

December 1 2026

Last Update

April 1 2024

Active Locations (1)

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1

UZ Leuven

Leuven, Vlaams-Brabant, Belgium, 3000