Inclusion Criteria:

• Patients presenting with bradykinesia, combined with resting tremor and/or myotonia.
• Appendix CT suggested chronic appendicitis evaluated by two experienced experts.
• All subjects and their guardians give informed consent to the content of this study and sign informed consent.
• Normal coagulation function.
• If the patient had taken oral anti-PD drugs, it had been stable for at least 2 weeks at enrollment.

Exclusion Criteria:

• Treatment with dopamine blockers or dopamine depleters in doses and time courses consistent with drug-induced parkinsonism.
• Neuroimaging examination of presynaptic dopaminergic system function was normal.
• Patients who had suffered severe brain trauma or underwent complex craniotomy within 5 years prior to enrollment.
• Cognitive disorders that are not on the Parkinson's spectrum, such as Alzheimer's disease, frontotemporal dementia, and Niemann-Pick disease, have been diagnosed.
• People diagnosed with severe neuropsychiatric disorders (epilepsy, bipolar disorder, major depressive episode, etc.) according to DSM-V.
• Complicated with serious systemic diseases, disorders of consciousness, stroke, serious coronary heart disease, diabetes, liver and kidney diseases, and serious visual and hearing disorders.
• Patients with severe organic or functional dysphagia;Those who were deemed by the researcher to be unable to complete the visit and auxiliary examination as required by the study protocol.