Status:

RECRUITING

320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.

Lead Sponsor:

Johns Hopkins University

Collaborating Sponsors:

Canon Medical Systems, USA

Conditions:

Atrial Fibrillation

Eligibility:

All Genders

21+ years

Phase:

NA

Brief Summary

This study explores the relationship between myocardial fibrosis and patient outcomes in Atrial Fibrillation (AF), specifically after catheter ablation. It aims to use Cardiac CT, an accessible tool, ...

Detailed Description

Atrial Fibrillation (AF) is the most common arrhythmia and is associated with significant healthcare-related expenses. With the aging population, the prevalence of AF is increasing. AF frequently co-e...

Eligibility Criteria

Inclusion Criteria:

  • Patients must be at least 21 years old at the time of enrollment.
  • Patients must be able to give informed consent.
  • Patients with symptomatic paroxysmal/persistent atrial fibrillation (AF).
  • Eligible patients must be determined to be suitable candidates for ablation to treat AF by their cardiologist and/or electrophysiologists regardless of this protocol.
  • Patients are scheduled to have a pre-procedure cardiac CT upon the discretion of their electrophysiologists

Exclusion Criteria:

  • Known allergy to iodinated contrast media.
  • Elevated serum creatinine (> 1.5mg/dl) OR calculated creatinine clearance of < 60 ml/min (using the Cockcroft-Gault formula).
  • Patients with a positive urine or serum pregnancy test will be excluded from this study.
  • Patients with heart transplantation.
  • Patients with polymorphic ventricular tachycardia (VT) or presenting in electrical storm.
  • Presence of any other history or condition that the investigator feels would be problematic.
  • Patient with iodinated contrast administration for other reason 24 hours prior to investigational CT.
  • Patients who have a heart pacemaker, metallic foreign body (metal sliver) in their eye, or who have an aneurysm clip in their brain, mechanical heart valves and prosthetics that contain metal.
  • Patients with severe claustrophobia.

Key Trial Info

Start Date :

April 10 2025

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 1 2026

Estimated Enrollment :

100 Patients enrolled

Trial Details

Trial ID

NCT06308094

Start Date

April 10 2025

End Date

December 1 2026

Last Update

April 13 2026

Active Locations (1)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 1 (1 locations)

1

Johns Hopkins Hospital

Baltimore, Maryland, United States, 21287