Status:
RECRUITING
320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
Canon Medical Systems, USA
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
This study explores the relationship between myocardial fibrosis and patient outcomes in Atrial Fibrillation (AF), specifically after catheter ablation. It aims to use Cardiac CT, an accessible tool, ...
Detailed Description
Atrial Fibrillation (AF) is the most common arrhythmia and is associated with significant healthcare-related expenses. With the aging population, the prevalence of AF is increasing. AF frequently co-e...
Eligibility Criteria
Inclusion Criteria:
- Patients must be at least 21 years old at the time of enrollment.
- Patients must be able to give informed consent.
- Patients with symptomatic paroxysmal/persistent atrial fibrillation (AF).
- Eligible patients must be determined to be suitable candidates for ablation to treat AF by their cardiologist and/or electrophysiologists regardless of this protocol.
- Patients are scheduled to have a pre-procedure cardiac CT upon the discretion of their electrophysiologists
Exclusion Criteria:
- Known allergy to iodinated contrast media.
- Elevated serum creatinine (> 1.5mg/dl) OR calculated creatinine clearance of < 60 ml/min (using the Cockcroft-Gault formula).
- Patients with a positive urine or serum pregnancy test will be excluded from this study.
- Patients with heart transplantation.
- Patients with polymorphic ventricular tachycardia (VT) or presenting in electrical storm.
- Presence of any other history or condition that the investigator feels would be problematic.
- Patient with iodinated contrast administration for other reason 24 hours prior to investigational CT.
- Patients who have a heart pacemaker, metallic foreign body (metal sliver) in their eye, or who have an aneurysm clip in their brain, mechanical heart valves and prosthetics that contain metal.
- Patients with severe claustrophobia.
Key Trial Info
Start Date :
April 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06308094
Start Date
April 10 2025
End Date
December 1 2026
Last Update
April 13 2026
Active Locations (1)
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1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287