Inclusion Criteria:

• Age 18 - 55 years
• Must not have performed regular lower-limb resistance training for the last 6 months (participants must have performed < 1 lower-limb resistance training session per week over the previous 6 months)
• DMRC Staff member (civilian or service personnel)

Exclusion Criteria:

• Any medical contraindication related to BFR*.

• Any current lower-limb musculoskeletal injury

• Restricted range of movement. i.e. Chronically locked knee or fixed flexion deformity.

• Any physical impairment or co-morbidities (including cardio-vascular disease) precluding the safe participation in the intervention and/or assessment procedures

• Non-musculoskeletal or serious pathological condition (i.e. Inflammatory arthropathy, infection or tumour).

• Use of any medication which may contraindicate the performance of BFR or influence blood biomarkers of EIMD or inflammation.

• Use of any performance enhancing supplements or ergogenic aids such as creatine monohydrate.

• Any individual who is known to be currently pregnant

  *Medical-based Exclusion Criteria (based on clinical contraindications to performing BFR):

• History of cardiovascular disease (hypertension, peripheral vascular disease, thrombosis/embolism, ischaemic heart disease, myocardial infarction).

• History of the following musculoskeletal disorders: rheumatoid arthritis, avascular necrosis or osteonecrosis, severe osteoarthritis.

• History of the following neurological disorders: Peripheral neuropathy, Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, severe traumatic brain injury.

• Varicose veins in the lower-limb.

• Acute viral or bacterial upper or lower respiratory infection at screening.

• Known or suspected lower limb chronic exertional compartment syndrome (tourniquet raises intra-compartmental muscle pressure).

• Postsurgical swelling.

• Surgical insertion of metal components at the position of cuff inflation.

• History of any of the following conditions or disorders not previously listed: diabetes, active cancer.

• History of elevated risk of unexplained fainting or dizzy spells during physical activity/exercise that causes loss of balance

• Increased risk of haemorrhagic stroke, exercise induced rhabdomyolysis.