Status:
RECRUITING
Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer
Lead Sponsor:
Blokhin's Russian Cancer Research Center
Conditions:
Colorectal Cancer Metastatic
Brain Metastases, Adult
Eligibility:
All Genders
18+ years
Brief Summary
GENCONCOR-1 study is translational research aimed to investigate the concordance of the molecular genetic profile of the primary tumor and brain metastases (BM) of colorectal cancer (CRC). The study w...
Detailed Description
Brain metastases (BM) from colorectal cancer (CRC) are a rare event reported in less than 3% of patients with CRC (the reported incidence ranges from 0.27 to 3%). This course is associated with a poor...
Eligibility Criteria
Inclusion Criteria:
- Men and women over 18 years of age.
- Histologically confirmed cancer of the colon or rectum.
- Histologically confirmed metastatic lesion of the brain.
- Neurosurgical resection for brain metastases of colorectal cancer.
- Presence of paired tumor samples (both primary tumor and intracranial material).
Exclusion Criteria:
- Missing one sample from a pair of tumor samples.
- Low quality or lack of tumor material for molecular genetic research.
Key Trial Info
Start Date :
April 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06449989
Start Date
April 1 2024
End Date
September 1 2027
Last Update
August 12 2025
Active Locations (1)
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1
Blokhin's Russian Cancer Research Center
Moscow, Moscow, Russia, 115478