Status:
RECRUITING
Respiratory Mechanics Measurement of Ventilated Patients Through Low-frequency Oscillometry Technique
Lead Sponsor:
Universitair Ziekenhuis Brussel
Conditions:
Ventilator Lung
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Respiratory failure has historically been one of the most important causes for admittance of patients to the critical care unit. This problem was the most important reason during the COVID-19 pandemic...
Eligibility Criteria
Inclusion
- intubation
- Controlled ventilation with an intention to continue controlled ventilation for the following 4 hours.
- Richmond agitation sedation scale of -4 or less
- Hemodynamically stable patient with either
- unchanged vasopressor dose administration for at least 60 minutes before the start of the measurements
- no vasopressor need and no vasopressor initiated within 60 minutes of measurements
- No planned intervention in the coming 2 hours
- Survival for at least 48 hours
- Protective ventilation (inspired oxygen concentration≤60%, plateau pressure ≤30 cmH2O , driving pressure≤ 15cmH2O)
- PEEP (Positive End Expiratory Pressure) ≤10
Exclusion
- assist ventilation
- Ventilator asynchronies
- Intermittent spontaneous breathing
- nitric oxide therapy
- presence of an extra corporeal membrane oxygenation device
- Ventilation is not possible within the lower and upper inflection point of the low flow pressure volume curve.
- Unstable right heart failure
- Unstable lung embolism
- Standard of care without Sedline® or invasive arterial catheter
- Do not reanimate code of 2, 3 or 4
- Subjects who are healthy, minors, pregnant women, patients in emergency situation
- Outside the age range 18 to 84 years
Key Trial Info
Start Date :
September 18 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT06483529
Start Date
September 18 2023
End Date
December 31 2024
Last Update
July 3 2024
Active Locations (1)
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1
Universitair Ziekenhuis Brussel
Jette, Brussel Hoofstedelijk Gewest, Belgium, 1090