Status:
NOT_YET_RECRUITING
Effectiveness of Periodontitis Treatment on the Metabolic Activity of Symptomatic Carotid Atherosclerotic Plaque Responsible for Ischemic Stroke
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Severe Periodontitis
Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cardiovascular disease is the world's leading cause of death. Atherothrombosis is a common cause of ischemic stroke. A strong epidemiological link has been established between periodontitis and the r...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Minor ischemic stroke of the anterior circulation (NIHSS ≤ 5) of atherothrombotic origin according to the TOAST scale \<30 days
- Atheroma plaque of the ipsilateral carotid bulb \>30% not eligible for intervention (endarterectomy or angioplasty-stenting)
- Severe periodontitis (stage 3 or 4)
- Signed informed consent
- Affiliation to a social security scheme
Exclusion
- \< 6 teeth
- Without independent oral hygiene
- Contraindications to PET scan
- Known allergy to fluoro-deoxyglucose and its excipient
- Immunosuppressive treatment
- Uncontrolled diabetes
- High risk of infective endocarditis
- Organ transplant pending
- Progressive infectious diseases
- Active smoking not stopped
- Patient deprived of liberty by judicial or administrative decision
- Patient under legal protection (guardianship, curatorship)
- Participation in another interventional research involving humans or being in the exclusion period following previous research involving humans
- Pregnant or breastfeeding woman Patient under AME (state medical aid)
Key Trial Info
Start Date :
September 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2028
Estimated Enrollment :
157 Patients enrolled
Trial Details
Trial ID
NCT06484036
Start Date
September 1 2024
End Date
September 1 2028
Last Update
July 3 2024
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