Status:
RECRUITING
Frontosubthalamic Networks in Parkinson's Disease.
Lead Sponsor:
University of Oxford
Conditions:
Parkinson Disease
Impulse Control Disorder
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this experimental study with is to understand the underlying mechanisms behind the increase in impulsivity seen in some patients that undergo deep brain stimulation of the subthalamic nucl...
Eligibility Criteria
Inclusion
- Participant is willing and able to give informed consent for participation in the study.
- Male or Female, aged 18 years or above.
- Diagnosed with Parkinson's disease who have required implanted STN electrodes for DBS in addition to their dopamine replacement therapy.
- Diagnosed with or without (control group) impulse control disorders since the diagnosis of Parkinson's Disease.
- Participant willing and able to sit in the MEG scanner and follow instructions.
- Participant willing and able to delay their morning dose of dopamine replacement therapy for up to four hours (180 minutes experimental time + journey time).
Exclusion
- Patients with extreme language barrier that cannot understand the purpose or instructions of the study despite the use of an interpreter.
- Other implanted medical devices that may cause artefacts during MEG recordings.
- Participants with a history of co-morbid neurological disorders.
- Participant enrolled onto another clinical trial related to a neurological disorder (including Parkinson's disease) that may interfere with the results of this study.
- Participants who are unable to sit still in a MEG scanner for the duration of this experiment e.g. patients with chronic pain or osteoarthritis. This will be assessed with their primary clinician
Key Trial Info
Start Date :
June 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06485986
Start Date
June 1 2024
End Date
August 31 2026
Last Update
April 2 2025
Active Locations (1)
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1
John Radcliffe Hospital
Oxford, United Kingdom, OX39DU