Status:
NOT_YET_RECRUITING
Comparison of the Antiplatelet Efficacy of Aspirin Combined With Clopidogrel and Aspirin Combined With Half-dose Ticagrelor in Patients With Unruptured Intracranial Aneurysms With Normal CYP2C19 Metabolizer Phenotype
Lead Sponsor:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Conditions:
Intracranial Aneurysms
Antiplatelet Drugs
Eligibility:
All Genders
20-70 years
Phase:
PHASE4
Brief Summary
The goal of this clinical trial is to compare the antiplatelet efficacy of aspirin combined with clopidogrel and aspirin combined with half-dose ticagrelor in in patients with unruptured intracranial ...
Eligibility Criteria
Inclusion
- Patients with unruptured intracranial aneurysms who are scheduled for stent-assisted embolization;
- mRS score less than or equal to 2 on admission;
- Normal CYP2C19 metabolizer genotype;
- Age 20 or above, 70 or below, regardless of gender;
- The subject or the entrusted family member voluntarily signed the informed consent for this trial
Exclusion
- Use of drugs that affect coagulation function or significant abnormalities in platelet/coagulation function before admission;
- Previous history of cardiovascular and cerebrovascular disease;
- Complications of major organ dysfunction, chronic inflammatory diseases or malignant tumors at admission;
- Known allergy or contraindication to heparin, aspirin, clopidogrel, or ticagrelor;
- Patients with any severe or active pathological bleeding;
- Pregnant and lactating female;
- Those deemed unsuitable to participate in this trial by the responsible physician
Key Trial Info
Start Date :
August 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2027
Estimated Enrollment :
196 Patients enrolled
Trial Details
Trial ID
NCT06486363
Start Date
August 1 2024
End Date
July 31 2027
Last Update
July 29 2024
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