Status:
COMPLETED
N-Acetyl Cysteine Effect on Liver Function After Mitral Valve Replacement
Lead Sponsor:
Kasr El Aini Hospital
Conditions:
Oxidative Stress
Liver Dysfunction
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
This study aimed at the impact of the N-acetyl cysteine on the improvement of liver function subsequently on-pum mitral valve replacement. Following a clinical trial design, 54 candidates of on-pump M...
Detailed Description
In a randomized controlled prospective study conducted in a teaching hospital, after approval by the ethics committee and informed consent, 54 candidates for on-pump MVR, aged 18 to 70 years, with nor...
Eligibility Criteria
Inclusion
- Age from 18 to 70 years
- Both sexes
- Patients undergoing on-pump elective MVR with cold cardioplegia.
Exclusion
- Patient refusal.
- Allergy to any of the study medications.
- Emergency procedures.
- systolic dysfunction, left ventricular ejection fraction \<40%.
- Pre-existing hepatic dysfunction, which is defined as an increase in liver enzymes AST and ALT \>10 times the baseline.
- chronic use of drugs affecting liver functions, e.g., NSAIDs, steroids, and anticonvulsants.
Key Trial Info
Start Date :
June 30 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2024
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT06486805
Start Date
June 30 2024
End Date
December 30 2024
Last Update
August 29 2025
Active Locations (1)
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1
Kasralainy Faculty of Medicine
Cairo, Egypt