Status:
RECRUITING
Duration of Peripheral Nerve Blocks in Opioid Tolerant Individuals - A Volunteer Blinded Matched Case-control Study
Lead Sponsor:
Charlotte Runge
Conditions:
Nerve Block
Opioid Tolerance
Eligibility:
All Genders
18-84 years
Phase:
NA
Brief Summary
Do peripheral nerve blocks work shorter if you are on opioids? Background: Peripheral nerve blocks effectively alleviate postoperative pain. Animal studies and human research indicate that opioid to...
Eligibility Criteria
Inclusion
- Inclusion criteria for opioid group
- Age \> 18 years old
- ASA 1-3
- Chronic pain, defined as persisting pain for more than three months
- Daily use of more than 60 mg of morphine equivalent in more than 7 days
- Legally competent and able to give informed consent
- Inclusion criteria for the opioid naive control group
- Age \> 18 years old
- ASA 1-3
- No use of opioids within 30 days prior to participation
- Legally competent and able to give informed consent
- Exclusion Criteria:
- Age \> 84 years old
- Volunteers who cannot cooperate with the study
- Volunteers who cannot understand or speak Danish
- Allergy to the lidocaine or the preservatives used in the study
- Alcohol or drug abuse other than opioids
- Peripheral neuropathy at the upper limb non-dominant arm
- Pathology or previous major surgery to the upper limb
- Active signs of infection in the cutaneous area of injection
- Pregnancy at the time of the trial
- Partial or complete 2nd or 3rd degree atrioventricular heart block without a pacemaker
- Severe liver disease
- Severe kidney disease and reduced kidney function (eGFR below 30 mL/min)
- Daily treatment with drugs that are structurally related to local analgesics or class IB antiarrhythmics, as the toxic effects are additive
- Daily treatment with class III antiarrhythmics e.g., amiodarone.
Exclusion
Key Trial Info
Start Date :
June 17 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06488768
Start Date
June 17 2024
End Date
May 1 2025
Last Update
July 5 2024
Active Locations (1)
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1
Silkeborg Regional Hospital
Silkeborg, Denmark, 8600