Status:
NOT_YET_RECRUITING
The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty
Lead Sponsor:
F. Johannes Plate
Conditions:
Arthritis Knee
Knee Osteoarthritis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Pain control and early range of motion following total knee arthroplasty are essential for patient satisfaction. Intraoperative steroids (dexamethasone) have been shown to have a significant effect in...
Eligibility Criteria
Inclusion
- Patients indicated for primary total knee arthroplasty.
- Access to computer or smartphone for completion of REDCap surveys
Exclusion
- Patients less than 18 years of age, patients unable to consent, known diabetic patients and those with an HgbA1c \>6.5 preoperatively, patients who are on chronic steroid treatments, patients with chronic pain on opioid management, patients with allergies to steroids, patients with a history of peptic ulcer disease, patients with a history of heart failure and patients with a history of renal and/or hepatic failure will be excluded. Those that are immunosuppressed as well as pregnant and/or lactating will also be excluded.
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06489626
Start Date
November 1 2025
End Date
December 1 2027
Last Update
October 7 2025
Active Locations (2)
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1
UPMC East
Monroeville, Pennsylvania, United States, 15146
2
UPMC Shadyside Hospital
Pittsburgh, Pennsylvania, United States, 15232