Status:
COMPLETED
Predicting the Efficacy in Advanced Gastric Cancer.
Lead Sponsor:
City of Hope Medical Center
Conditions:
Gastric Cancer
Chemotherapy Effect
Eligibility:
All Genders
20+ years
Brief Summary
With advances in chemotherapy for gastric cancer, it is important to identify patients who will respond effectively to specific therapies. This longitudinal study aimed to establish a liquid-biopsy as...
Detailed Description
The combination of paclitaxel and ramucirumab is a potent standard second-line therapy for patients with advanced gastric cancer, but approximately 30% of patients do not respond to treatment. Failure...
Eligibility Criteria
Inclusion
- unresectable or recurrent GC histologically confirmed to be primary adenocarcinoma of the stomach.
- age over 20 years.
- Eastern Cooperative Oncology Group performance status score of 0-2.
- written informed consent following full study information is provided to the patient.
- progression or intolerance for first-line chemotherapy comprising fluorinated pyrimidine and platinum anticancer drugs (cisplatin or oxaliplatin) for advanced GC.
- presence of evaluable lesions as confirmed using a computed tomography (CT) or magnetic resonance imaging.
Exclusion
- Patients with a life expectancy of shorter than 3 months
- Patients with severe complications (angina pectoris, myocardial infarction, or arrhythmia) or uncontrollable diabetes mellitus, blood hypertension, or bleeding tendency.
- Patients with a history of serious allergic reactions or serious drug allergy.
- Patients with a clinically relevant mental disorder that prohibits response to questionnaires.
- Patients for whom the attending physician considered that enrollment in the study is inappropriate.
Key Trial Info
Start Date :
October 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2025
Estimated Enrollment :
162 Patients enrolled
Trial Details
Trial ID
NCT06490055
Start Date
October 1 2018
End Date
July 1 2025
Last Update
July 18 2025
Active Locations (2)
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1
Department of Molecular Diagnostics and Experimental Therapeutics
Monrovia, California, United States, 91016
2
Kawasaki Medical University
Kurashiki, Okayama-ken, Japan, 7010192