Status:
RECRUITING
Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients
Lead Sponsor:
New Valley University
Conditions:
Haemodynamic Rebound
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
PHASE2
Brief Summary
Inflammatory response and hemodynamic response in patients with intraabdominal sepsis and Effects of Dexmedetomidine versus ketamine on it .
Detailed Description
Severe sepsis is a major healthcare problem with a reported incidence of 1-2% in all hospitalizations. It is a major cause of death in intensive care units worldwide and is the second leading cause of...
Eligibility Criteria
Inclusion
- • Adult patients admitted to ICU after ileus surgery (perforated viscus, infarcted bowel, strangulated hernia, anastomotic leakage, diverticulitis, and intestinal obstruction), and who will be expected to require postoperative sedation and ventilation.
- Abdominal sepsis was determined as organ dysfunction with a substantial change in overall SOFA score (2) ≥ 2 points because of intra-abdominal sepsis.
Exclusion
- • Known allergy to ketamine, dexmedetomidine,
- Confirmed pregnancy,
- Heart failure (class 3 or 4 of the New York Heart Association),
- Renal failure (RIFLE classification),
- Liver failure (manifested by serum total protein concentration \<3 g/dl and total bilirubin \>5 mg/dl)
- Known or suspected brain death.
- Patients who receive neuromuscular blockers during the first 48 hours of ICU admission will also be excluded.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT06490731
Start Date
April 1 2025
End Date
January 1 2026
Last Update
May 22 2025
Active Locations (1)
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1
asyut University
Asyut, Egypt