Status:
RECRUITING
Spine Unit Modelling Coupled With hIgh Throughput Analysis (SUIT)
Lead Sponsor:
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Conditions:
Degenerative Disc Disease
Eligibility:
All Genders
18-60 years
Brief Summary
Ageing and inflammation represent two main drivers of DDD, a progressive, chronic condition involving vertebral bone, cartilaginous endplate and intervertebral disc. In vitro investigation of the DDD...
Detailed Description
The primary aim of this study is to investigate the response of an inflamed organotypic spine unit model, intended as a 3D in vitro representation of an in vivo environment, to the treatment with mese...
Eligibility Criteria
Inclusion
- DDD patients:
- Signature of the Informed Consent for the study
- Age 30-60 years (included)
- Pfirrmann grade III-V
- Need to undergo spinal surgery
- Subjects for the isolation of adipose-derived MSCs:
- Signature of the Informed Consent for the study
- Age 18-50 (included)
- Need to undergo surgery that involves the removal of adipose tissue
- Subjects for the isolation of placenta-derived MSCs:
- Signature of the Informed Consent for the study
- Age 18-50 (included)
- Women who are pregnant or who have not given birth from more than 6 hours
- All enrolled subjects:
- \- Presence of HIV, HBV, HCV or TP infection
Exclusion
Key Trial Info
Start Date :
June 28 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06490887
Start Date
June 28 2023
End Date
August 1 2025
Last Update
July 8 2024
Active Locations (2)
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1
IRCCS Ospedale Galeazzi-Sant'Ambrogio
Milan, MI, Italy, 20157
2
IStituto MEditerraneo per i Trapianti e Terapie ad alta specializzazione
Palermo, Italy, 90127