Status:
NOT_YET_RECRUITING
Effects of Mechanical Insufflation-Exsufflation With Optimized Settings on Wet Mucus Volume During Invasive Ventilation
Lead Sponsor:
Hospital Clinic of Barcelona
Conditions:
Mucus Retention
Mechanical Ventilation Complication
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Retention of airway secretions is a frequent complication in critically ill patients requiring invasive mechanical ventilation (MV).This complication is often due to excessive secretion production and...
Detailed Description
Retention of airway secretions is a frequent complication in critically ill patients requiring invasive mechanical ventilation (MV). This complication is often due to excessive secretion production an...
Eligibility Criteria
Inclusion
- Adults (\> 18yo).
- Endotracheal intubation and invasive mechanical ventilation for \> 48h and active humidification for \> 24h.
- Richmond Agitation-Sedation Scale -3 to -5.
- Signed informed consent.
Exclusion
- Patients with hemodynamic instability (MAP \< 60 or \> 110, Heart Rate \< 50 or \> 130, new onset arrhythmias), respiratory instability (PEEP \> 12cmH2O, SpO2 \< 90% or fraction of inspired oxygen (FiO2) \> 60%).
- Undrained pneumothorax/pneumomediastinum.
- Unstable intracranial pressure (ICP \> 20mmHg or MAP \< 60).
- Severe bronchospasm.
- Post cardiothoracic surgical patients.
- Active pulmonary tuberculosis.
- Bronchoesophageal or bronchopleural fistulas.
- Prone position.
- Pregnancy.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT06491017
Start Date
September 1 2025
End Date
December 1 2026
Last Update
May 23 2025
Active Locations (1)
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1
Hospital Clinic de Barcelona
Barcelona, Spain, 08036