Status:
RECRUITING
Evaluation of the Association Between Right Atrial Reservoir Strain Variation and Fluid Responsiveness in Patients With Septic Shock
Lead Sponsor:
Centre Hospitalier Universitaire, Amiens
Conditions:
Fluid Responsivness
Right Ventricle
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Evaluating preload dependence is crucial for managing fluid administration in septic shock patients. To avoid unnecessary fluid administration, it's recommended to use dynamic tests like the passive l...
Eligibility Criteria
Inclusion
- Adult patient (\>18 years old)
- Patient hospitalized in the Intensive Care Unit at Amiens University Hospital with septic shock for less than 48 hours, defined by the presence of all the following criteria: presence of sepsis, hypotension requiring vasopressors to maintain a mean arterial pressure ≥ 65 mmHg despite adequate prior fluid resuscitation, and blood lactate levels \> 2 mmol/l (18 mg/dl).
- Patient requiring fluid resuscitation with crystalloids/colloids
- Patient on invasive mechanical ventilation in assisted-controlled mode.
- Blood pressure monitored via a radial or femoral arterial catheter connected to a MostCareUp (Vygon, France).
- Patient or family informed and non-opposition documented.
Exclusion
- Poor echocardiographic image quality preventing RASr assessment
- Patient with a contraindication to the PLR maneuver: severe head trauma or intracranial hypertension
- Patient with a history of pericardiectomy
- Patient with a clinical examination consistent with abdominal compartment syndrome
- Patient with aortic pathology, mitral regurgitation greater than grade 2, tricuspid regurgitation greater than grade 2, mitral stenosis, or intracardiac shunt
- Patient with internal or external atrial/ventricular pacing
- Pregnant woman
- Patient on extracorporeal membrane oxygenation and mechanical circulatory support
- Moribund patient
- Patient with supraventricular or ventricular arrhythmia during echocardiographic measurement series
- Patient on renal replacement therapy during echocardiographic examination
Key Trial Info
Start Date :
October 10 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT06492044
Start Date
October 10 2022
End Date
December 1 2026
Last Update
July 10 2024
Active Locations (1)
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1
CHU Amiens Picardie
Amiens, France