Status:
RECRUITING
Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis
Lead Sponsor:
Emory University
Collaborating Sponsors:
National Multiple Sclerosis Society
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-89 years
Phase:
NA
Brief Summary
The study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine whether daily personalized gaze stabilization tra...
Detailed Description
People with multiple sclerosis (MS) often experience dizziness, caused by problems in how their brain processes balance signals. This dizziness can lead to difficulties keeping their eyes focused on a...
Eligibility Criteria
Inclusion
- Neurologist-confirmed diagnosis of primary progressive or relapsing and remitting MS per The 2017 Revision of the McDonald Criteria and the Magnetic Resonance Imaging in MS, or a healthy volunteer without a diagnosis of multiple sclerosis or any related neurological conditions
- Fluent in speaking and understanding English
- Subjects with multiple sclerosis have self-reported vestibular symptoms of dizziness, imbalance, and/or a history of at least two falls in the prior 12 months
Exclusion
- Clinically isolated syndrome or radiologically isolated syndrome.
- Worsening MS symptoms during the prior 60 days
- Immunotherapy change in the prior 60 days
- Self-reported cognitive impairment that limits independence with basic and instrumental activities of daily living
- Systolic blood pressure \> 180 mmHg and/or diastolic blood pressure \> 90 mmHg at rest
- Static visual acuity with correction of worse than 1.0 logMAR
- Manifest ocular misalignment ≥ 5 diopters (e.g., tropia, lazy eye, strabismus}
- Convergence insufficiency
- Intra-nuclear ophthalmoplegia
- Vestibular Migraine
- Major orthopedic conditions that limit cervical spine range of motion or that alter walking
- Self-reported current or potential for pregnancy during enrollment
- Ongoing participation in vestibular rehabilitation for dizziness
Key Trial Info
Start Date :
April 21 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2027
Estimated Enrollment :
138 Patients enrolled
Trial Details
Trial ID
NCT06495138
Start Date
April 21 2025
End Date
March 1 2027
Last Update
July 16 2025
Active Locations (1)
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1
Emory Univeristy
Atlanta, Georgia, United States, 30329