Status:

RECRUITING

Impact of Prebiotics in Ulcerative Colitis

Lead Sponsor:

University of California, Los Angeles

Conditions:

Crohn Disease

Ulcerative Colitis

Eligibility:

All Genders

18-85 years

Phase:

NA

Brief Summary

The cause of inflammatory bowel disease (IBD) is currently unknown, although partly attributed to interactions among genetic risk polymorphisms, environmental factors, gut microbiome, and host immunit...

Eligibility Criteria

Inclusion

  • Ages 18 to 85 years old
  • History of biopsy-proven ulcerative colitis (UC)
  • Active symptoms (SCCAI \>2)
  • Concomitant use of 5-aminosalicylates, immunomodulators, and corticosteroids will be permitted, although initiation or dose adjustment must not have occurred within 30 days prior to enrollment.
  • Concomitant use of biologic therapy will be permitted, although initiation or dose adjustment must not have occurred within 60 days prior to enrollment.
  • Prior probiotics or other dietary supplements use is permitted but will be asked to be discontinued during the course of the trial

Exclusion

  • Prior colectomy
  • Hospitalization
  • Urgent need for abdominal surgery
  • Unstable major medical condition
  • Active malignancy under treatment
  • Active alcohol or non-cannabinoid substance abuse
  • Pregnancy or lactation
  • Concerns for non-compliance

Key Trial Info

Start Date :

July 9 2024

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 31 2027

Estimated Enrollment :

70 Patients enrolled

Trial Details

Trial ID

NCT06495658

Start Date

July 9 2024

End Date

December 31 2027

Last Update

May 1 2025

Active Locations (1)

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Page 1 of 1 (1 locations)

1

UCLA

Los Angeles, California, United States, 90095