Status:
ENROLLING_BY_INVITATION
Efficacy and Safety of Systematic Therapy and Bronchoscopic Interventional Treatment for Pulmonary Mucormycosis
Lead Sponsor:
Beijing Tsinghua Chang Gung Hospital
Conditions:
Pulmonary Mucormycosis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Evaluation of the effectiveness and safety of transbronchoscopic local precision infusion of amphotericin B + transoral nebulized inhalation of amphotericin B + transbronchoscopic interventional debri...
Detailed Description
Key rationale for the treatment of mucormycosis is early surgical intervention, including local debridement and removal of infected tissues or organs if possible. Systemic antifungal therapy is also n...
Eligibility Criteria
Inclusion
- Subjects suspected of pulmonary mucormycosis by clinical radiology will be enrolled in the study if the pathologic or microbiological diagnosis of mucormycosis (smear showing sterile mycelium, culture or molecular evidence of mucormycosis) is confirmed.
- Cases of diffuse mucormycosis will only be included if lung infection is confirmed pathologically or microbiologically by respiratory secretions or biopsy samples.
- Ability to tolerate bronchoscopy.
Exclusion
- Pregnant and breastfeeding female patients
- Age \<18 years
- Patients with HIV infection
- Contraindications to bronchoscopy (including platelet count \< 100 x 109/L, active hemoptysis, severe respiratory or heart failure, severe arrhythmia, unstable angina or hypertension, severe pneumothorax or mediastinal emphysema, patients with acute myocardial infarction, cerebral infarction, and cerebral hemorrhage within 3 months
- Patients unable to tolerate bronchoscopy
Key Trial Info
Start Date :
July 30 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06495905
Start Date
July 30 2024
End Date
December 30 2025
Last Update
July 11 2024
Active Locations (1)
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1
Beijing TsingHua ChangGung hospital
Beijing, Beijing Municipality, China