Status:
ACTIVE_NOT_RECRUITING
Echocardiography-guided Percutaneous Septal Radiofrequency Ablation for Obstructive HCM After Alcohol Septal Ablation
Lead Sponsor:
Xijing Hospital
Conditions:
Hypertrophic Cardiomyopathy
Eligibility:
All Genders
18-80 years
Brief Summary
After alcohol ablation, some HOCM patients have serious clinical symptoms and adverse complications, and need to undergo invasive surgery again when adequate drug therapy is not effective or cannot to...
Detailed Description
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease, mostly due to mutations in the gene encoding myocardial sarcomere contractile protein, with an incidence of about...
Eligibility Criteria
Inclusion
- The patient is at least 18 years of age.
- Hypertrophic cardiomyopathy with alcohol ablation, LVOT pressure difference at rest or after excitation ≥ 50mmHg;
- The clinical symptoms are obvious, fatigue, shortness of breath, exhaustive angina pectoris, syncope, etc. seriously affect the quality of life, and the effect of adequate drug treatment is not good or the side effects of drugs cannot be tolerated;
- After the informed consent of the patient and his family, he voluntarily underwent Liwen surgery.
Exclusion
- Non-obstructive hypertrophic cardiomyopathy;
- Left ventricular hypertrophy due to secondary causes, such as increased preload, history of taking drugs suspected of causing left ventricular hypertrophy, etc.
- Preoperative complications with other heart diseases require surgical treatment.
- The disease will make it difficult to evaluate treatment (e.g. cancer, severe metabolic diseases, mental illness, etc.).
- Patients who have participated in any clinical trial of drugs and/or medical devices within 1 month before surgery or during follow-up;
- Pregnant and breastfeeding women;
- Patients with poor adherence may not cooperate during treatment or follow-up.
Key Trial Info
Start Date :
March 26 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06496633
Start Date
March 26 2024
End Date
December 31 2024
Last Update
July 11 2024
Active Locations (1)
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1
Ultrasonic Diagnosis Department of Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China, 710032