Status:
RECRUITING
Ketamine for Methamphetamine Use Disorder
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Substance Use Disorders
Substance Use
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
This study aims to determine whether treatment response with IV ketamine is superior to treatment response with IV midazolam in adults with moderate to severe MUD. The study design is a 12-week rando...
Detailed Description
Effective management for methamphetamine use disorder (MUD) remains elusive, despite widespread misuse of this stimulant. Psychological interventions have demonstrated modest benefits, and relapse rat...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Study participants must:
- Be 18 to 65 years old
- Be able to sufficiently understand, speak, and read English
- Be interested in reducing or stopping methamphetamine use
- Meet criteria for methamphetamine use disorder
- Use acceptable methods of contraception during participation in the study
- Exclusion criteria
- Study participants must not:
- Have been in a research study of pharmacological or behavioral treatment for addiction within 6 months prior to written informed consent
- Be currently in jail, prison, or inpatient overnight facility as required by court of law
- Have upcoming surgery planned or scheduled
- Be currently pregnant, breastfeeding, or planning on conception, if biologically female
- Additional inclusion and exclusion criteria will be assessed by the study investigators at the screening visit.
Exclusion
Key Trial Info
Start Date :
September 11 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 15 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06496750
Start Date
September 11 2024
End Date
October 15 2026
Last Update
November 21 2025
Active Locations (4)
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1
Interdisciplinary Substance Use and Brain Injury Facility
Albuquerque, New Mexico, United States, 87106
2
Addiction Institute of Mount Sinai
New York, New York, United States, 10029
3
Prisma Health
Greenville, South Carolina, United States, 29617
4
UT Southwestern Medical Center
Dallas, Texas, United States, 75247