Status:
RECRUITING
A Comparative Study of Glucocorticoids Efficacy in Acute Respiratory Distress Syndrome
Lead Sponsor:
Fayoum University
Conditions:
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
Phase:
PHASE2
PHASE3
Brief Summary
The aim of the work is to compare the efficacy of equivalent doses of methylprednisolone, dexamethasone and hydrocortisone in patients with ARDS
Detailed Description
Acute respiratory distress syndrome (ARDS) is a secondary disease that follows-usually within 6-48 h-a primary disease of multifactorial etiology (most frequently pneumonia and extrapulmonary sepsis) ...
Eligibility Criteria
Inclusion
- We include patients receiving mechanical ventilation for hypoxemic respiratory failure if they met the diagnostic criteria for ARDS according to the American-European Consensus definition, as later reclassified on the basis of the 2012 Berlin criteria for the diagnosis of ARDS, defined as:
- Presence of acute hypoxemic respiratory failure (an arterial oxygen partial pressure to fraction of inspired oxygen ratio (PaO2/FiO2) of ≤ 300 mm Hg, requiring supplemental oxygen administrated by simple face mask, nasal cannula, or other similar oxygen-delivery device to maintain oxygen saturation at greater than 93% within the first 48 h of the onset of ARDS)
- Onset within 7 days of insult, or new (within 7 days) or worsening respiratory symptoms
- Bilateral opacities on chest x-ray or CT not fully explained by effusions, lobar or lung collapse, or nodules
- Cardiac failure not the primary cause of acute respiratory failure
Exclusion
- We exclude patients with acute hypoxemic respiratory failure caused by congestive heart failure
Key Trial Info
Start Date :
August 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06496997
Start Date
August 1 2024
End Date
September 1 2025
Last Update
January 6 2025
Active Locations (1)
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1
Fayoum University
Al Fayyum, Egypt