Status:
NOT_YET_RECRUITING
Single-Cell Insights Into Diabetic Retinopathy Mechanisms
Lead Sponsor:
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Conditions:
Diabetic Retinopathy
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to uncover the cellular and molecular mechanisms of diabetic retinopathy through single-cell sequencing to identify new therapeutic targets. The study will collect retinal tissue samp...
Detailed Description
Diabetic retinopathy is the leading cause of blindness among the working population worldwide. However, its pathogenesis is not fully understood, and effective prevention and treatment methods are lim...
Eligibility Criteria
Inclusion
- Inclusion Criteria :
- For the single-cell sequencing group: Patients with advanced proliferative diabetic retinopathy (PDR) resulting in blindness or ocular atrophy, who voluntarily opt for enucleation and ocular prosthesis implantation surgery, and have no systemic or local contraindications to surgery. For the validation group: patients with severe PDR lesions requiring vitrectomy, and who also have no systemic or local contraindications to surgery.
- Patients who voluntarily agree to participate in this clinical trial and sign the informed consent form.
- Exclusion Criteria:
- Patients with severe systemic diseases such as autoimmune diseases or cancer
Exclusion
Key Trial Info
Start Date :
July 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2027
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT06497608
Start Date
July 1 2024
End Date
July 1 2027
Last Update
July 12 2024
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