Status:
RECRUITING
The Underlying Mechanisms Regarding the Effect of Glucagon on the Kidneys Will be Investigated in Healthy Males.
Lead Sponsor:
Ali Asmar
Collaborating Sponsors:
University of Copenhagen
The Augustinus Foundation, Denmark.
Conditions:
Kidney Diseases
Eligibility:
MALE
20-60 years
Phase:
NA
Brief Summary
The goal of this crossover study is to investigate to what extend glucagon affects the kidneys. The main questions it aims to answer are: Does glucagon regulate kidney function through extraction in ...
Detailed Description
In patients with type 2 diabetes mellitus, plasma concentrations of glucagon are inappropriately high (hyperglucagonemia). Hyperglucagonemia has been speculated to contribute to the pathophysiology of...
Eligibility Criteria
Inclusion
- Age: 20-60 years
- Normal health ascertained through questioning and medical examination
- Normal values for blood concentrations of fasting plasma glucose, fasting plasma total cholesterol, fasting triglycerides, HDL, LDL, creatinine, liver function, and electrolytes
- Informed consent
Exclusion
- Immunosuppressive treatment in the preceding 12 months
- Alcohol abuse
- Medical treatment with oral glucocorticoids, dipeptidyl peptidase-4 (DPP-4) inhibitors, or GLP-1 receptor agonists, which, in the opinion of the investigator, may interfere with glucose metabolism
- Use of lithium
- Medical treatment that affects insulin secretion or cardiovascular performance measures
- Liver disease (ALT \> 2x normal value)
- Renal impairment (se-creatinine \> 130 μM and/or albuminuria)
Key Trial Info
Start Date :
February 20 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2025
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT06498063
Start Date
February 20 2024
End Date
July 31 2025
Last Update
July 12 2024
Active Locations (1)
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1
Physiological laboratory, Bispebjerg Hospital, Research Unit, Clinical Physiology / Nuclear Medicine Department
Copenhagen, Denmark, 2400