Status:
NOT_YET_RECRUITING
Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus
Lead Sponsor:
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Conditions:
Oral Lichen Planus
Periodontal Diseases
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The purpose of this clinical trial is to understand whether the combination of periodontal initial treatment under local anesthesia and glucocorticoids can improve the effectiveness of treatment for e...
Eligibility Criteria
Inclusion
- Existence of erosive oral lichen planus that lasts for more than 2 months
- Erosive lesions are located in the buccal mucosa and gingival buccal sulcus of the bilateral mandibular posterior teeth area
- The erosive lesions are mild to moderate (single or multiple small area erosions; 3mm ≤ longest diameter ≤ 10mm; 9mm2 ≤ total area of erosions ≤ 100mm2), and the degree of erosion on both sides is similar (the difference in the size of erosion on both sides does not exceed ± 25%)
- The plaque index in the area of erosive lesions is ≥ 3; Dental calculus index ≥ 2; Gingival index ≥ 2;
- Accompanied by stage II-IV extensive periodontitis
Exclusion
- Pregnant women, lactating women, or women planning to conceive during the trial period
- Patients with coagulation dysfunction or other uncontrolled systemic diseases who cannot undergo periodontal treatment
- Has undergone basic periodontal treatment within the past 6 months
- Individuals with a history of allergy to local anesthetic drugs such as articaine
- Individuals with contraindications to glucocorticoids
- Patients with lesion area erosion caused by trauma or chemical stimulation
- Patients with mental disorders who are difficult to cooperate with treatment
Key Trial Info
Start Date :
December 31 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2028
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT06498180
Start Date
December 31 2024
End Date
March 31 2028
Last Update
July 12 2024
Active Locations (1)
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1
Shanghai Ninth People's Hospital
Shanghai, Shanghai Municipality, China, 200011