Status:
RECRUITING
Norepinephrine Equivalent Dose of Vasopressin, Phenylephrine and Epinephrine in Septic Shock
Lead Sponsor:
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Conditions:
Septic Shock
Eligibility:
All Genders
18-80 years
Brief Summary
Septic shock is the most common form of circulatory shock encountered in patients admitted in intensive care unit. The initial management involves fluid resuscitation but if hypotension does not get r...
Detailed Description
Sepsis is a life-threatening state of organ dysfunction caused by dysregulated response of host to infection. It is the most common form of circulatory shock encountered in patients admitted in intens...
Eligibility Criteria
Inclusion
- All adult patients on mechanical ventilation in septic shock receiving norepinephrine in whom the treating clinical team plan to add another vasopressor, will be considered for inclusion if they meet these two condition (1) Patient is on Norepinephrine infusion at least 0.1 mcg/kg/min for the last 6 hours; and (2) There has been no dose alteration in the infusion of norepinephrine for the last 2 hours
Exclusion
- There are concurrently other forms of shock like cardiogenic, obstructive, anaphylactic or hypovolemic.
- The patient has arrhythmias during the current course of illness.
- The patient has asynchrony on mechanical ventilator despite airway clearance with suctioning and adequate sedation at the time of study measurement.
- The patient is hypovolemic with ongoing fluid resuscitation in the form of fluid boluses, blood or blood product transfusions at the time of study measurement.
- The patient receives diuretic boluses or undergoes hemodialysis sessions at the time of study measurement.
- Pregnancy
- Patient who didn't consent for study or withdrew the consent at any point of the study.
Key Trial Info
Start Date :
July 12 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06499467
Start Date
July 12 2024
End Date
January 1 2026
Last Update
July 16 2024
Active Locations (1)
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1
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, India, 226014