Status:
RECRUITING
HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
University Hospital Heidelberg
Conditions:
Acute Mountain Sickness
Eligibility:
All Genders
18-44 years
Phase:
PHASE4
Brief Summary
Millions of people travel to high altitude for work or leisure activities and are exposed to reduced inspiratory oxygen partial pressure and hypoxemia that may lead to altitude illness, among which th...
Eligibility Criteria
Inclusion
- Healthy, non-smoking men and women, age 18-44 years, without any disease and need of regular medication (including oral contraceptives).
- BMI \>18 kg/m2 and \<30 kg/m2
- Born, raised and currently living at altitudes \<1000 m
- Written informed consent
- Premenopausal women with an eumenorrheic cycle
Exclusion
- Other types of contraceptvies (contraceptives (hormonal intrauterine device, vaginal ring, subcutaneous injections or implants, among others)
- Pregnancy or nursing
- Anaemic (haemoglobin concentration \<10g/dl)
- Any altitude trip \<4 weks before the study
- Allergy to acetazolamide and other sulfonamides
Key Trial Info
Start Date :
July 15 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
270 Patients enrolled
Trial Details
Trial ID
NCT06499727
Start Date
July 15 2024
End Date
December 31 2025
Last Update
June 13 2025
Active Locations (1)
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1
National Center for Cardiology and Internal Medicine
Bishkek, Gorod Bishkek, Kyrgyzstan, 720040