Status:
RECRUITING
Links Between Cognitive Deficits During Normal or Pathological Aging and Slow Waves Measured in EEG
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Aging
Alzheimer Disease
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
With age, memory processes (encoding, consolidation and retrieval) as well as daytime vigilance are altered. Sleep is also impaired in older adults, notably slow waves that are known to play a key rol...
Detailed Description
Introduction Aging is accompanied by cognitive decline, particularly affecting memory functions. Additionally, both the quantity and quality of sleep decrease with advancing age, specifically altering...
Eligibility Criteria
Inclusion
- Common Inclusion Criteria for All Three Groups:
- Male or female Signed informed consent Affiliated with a social security system Native French speakers Completed at least 7 years of schooling (minimum 9th grade level)
- Specific Inclusion Criteria for Each Group:
- Patients:
- Age: 60 to 85 years Prodromal stage of Alzheimer's disease diagnosed according to international diagnostic criteria, characterized by a clinical phenotype of progressive amnesic syndrome of the hippocampal type, associated with biological markers of Alzheimer's disease from lumbar puncture (Aβ \< 600 pg/mL and ptau \> 60 pg/mL)
- Cognitively Healthy Seniors:
- Age: 60 to 85 years Age and sex matched with the Patients group "Cognitively healthy" status defined by a score of ≥ 26 on the MMSE (Mini-Mental State Examination), a score of ≥ 16 on the BREF (Batterie Rapide d'Efficience Frontale), and a score of ≥ 8 on the 5-word test
- Young Adults:
- Age: 18 to 35 years Sex matched with the Patients group "Cognitively healthy" status defined by a score of ≥ 26 on the MMSE (Mini-Mental State Examination), a score of ≥ 16 on the BREF (Batterie Rapide d'Efficience Frontale), and a score of ≥ 8 on the 5-word test
Exclusion
Key Trial Info
Start Date :
April 24 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2027
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06501495
Start Date
April 24 2025
End Date
April 1 2027
Last Update
May 1 2025
Active Locations (1)
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1
Maladies du Sommeil
Paris, France, 75013