Status:
COMPLETED
Pilot Study: Use of the Saccadometer to Detect Characteristic Saccadic Peak Velocity in Myasthenia Gravis Patients
Lead Sponsor:
University of Liverpool
Collaborating Sponsors:
Liverpool University Hospitals NHS Foundation Trust
Conditions:
Myasthenia Gravis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Fast eye movements have been shown to demonstrate characteristics that are specific to myasthenia gravis that are not present in other eye movement disorders. It is possible to measure these eye movem...
Detailed Description
The diagnosis of Myasthenia Gravis (MG) can be challenging, particularly in its ocular manifestation with current clinical procedures. Previous research has shown that fast eye movements in patients s...
Eligibility Criteria
Inclusion
- Patient participants
- Confirmed diagnosis of Myasthenia Gravis by either a positive acetylcholine antibody serum test (AChR) and/or a positive single fibre electromyograph (SFEMG) test.
- Patient participants must have also had at least one episode of diplopia and/or eye movement abnormality attributed to their diagnosis of MG.
- Healthy participants:
- Must have no history of eye movement abnormality
- No have no history of other auto-immune disease (specifically diabetes, Thyroid Eye Disease and Chronic External Ophthalmoplegia).
Exclusion
- Patients without confirmed Myasthenia Gravis diagnosis by means of either a positive AChR serum test and/or a positive SFEMG test.
- Patients with confirmed Myasthenia Gravis who have not had at least one episode of diplopia and or ptosis.
- Patients with current or previous episodes of ocular motility dysfunction that have a confirmed diagnosis other than Myasthenia Gravis.
- Any healthy participant found to have an abnormality of vision or eye movement upon screening or a history of auto-immune disease.
Key Trial Info
Start Date :
March 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2018
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06501794
Start Date
March 1 2016
End Date
March 1 2018
Last Update
December 18 2024
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